Results 91 to 100 of about 3,053,426 (341)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Gödel’s Philosophical Challenge (to Turing)

open access: yesStudia Semiotyczne, 2020
DOI: http://doi.org/10.26333/sts.xxxiv1.03 The incompleteness theorems constitute the mathematical core of Gödel’s philosophical challenge. They are given in their “most satisfactory form”, as Gödel saw it, when the formality of theories to which they
Wilfried Sieg
doaj  

On computable subgroups of the group of all unitriangular matrices over a ring

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2017
The problems of existence and uniqueness of computable numberings are fundamental in theory of computably numbered groups. In connection with the development of the theory of algorithms a study of the problems of computability of important classes of ...
R.K. Tyulyubergenev
doaj   +1 more source

Computational Toxicology [PDF]

open access: yesChemical Research in Toxicology, 2020
Nicole C. Kleinstreuer   +2 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

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