Results 71 to 80 of about 27,920 (229)
Computational models for parallel computers [PDF]
Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences, 1988 Computational models define the usage patterns of a computer. They can be used to derive the architecture of the machine, provide guidelines for programming tools, and suggest how the machine should be used in applications. Identifying computational models is especially important for parallel computers, because their architectures and usages are still ...
openaire +2 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
A Primer on the Tools and Concepts of Computable Economics [PDF]
, 2004 Computability theory came into being as a result of Hilbert's attempts to meet Brouwer's challenges, from an intuitionistc and constructive standpoint, to formalism as a foundation for mathematical practice.
Velupillai, K. Vela
core +1 more source
ACM Computing Surveys, 1985 Computer animation may be defined as a technique in which the illusion of movement is created by displaying on a screen or recording on a device a series of individual states of a dynamic scene. The key issue of computer animation is defining motion, commonly known as motion control methods (MCMs).
Magnenat Thalmann, N, Thalmann, D
openaire +5 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
, 2007 In this paper we settle most of the open questions on algorithmic computability of Julia sets. In particular, we present an algorithm for constructing quadratics whose Julia sets are uncomputable.
Braverman, Mark, Yampolsky, Michael
core +3 more sources
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source