Results 121 to 130 of about 3,148,089 (334)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Computers and Computing in Society [PDF]

open access: yesNTM Zeitschrift für Geschichte der Wissenschaften, Technik und Medizin, 2020
openaire   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

EXAMINING ORAL TEST ACCOMMODATION IN ASSESSING MALAYSIAN ORANG ASLI PUPILS’ MATHEMATICS PERFORMANCE FOR COMPUTATION AND WORD PROBLEM TESTLETS

open access: yesMalaysian Journal of Learning and Instruction
Purpose - The language load within mathematics test items can lead to inaccuracy in assessing Orang Asli pupils’ mathematical ability due to their struggle in comprehending the academic language.
Arsaythamby Veloo   +2 more
doaj   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Art and Language After AI

open access: yesTechnophany
By ingesting a vast corpus of source material, generative deep learning models are capable of encoding multi-modal data into a shared embedding space, producing synthetic outputs which cannot be decomposed into their constituent parts.
Anil Bawa-Cavia
doaj   +1 more source

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