Results 121 to 130 of about 188,569 (212)

NCBoost v2: a classifier for non-coding single-nucleotide variants in Mendelian diseases. [PDF]

Bioinformatics
Caron B, Rausell A.
europepmc   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

TSEDTA: a transformer-based neural network with SMILES transformer and ESM2 embeddings for drug-target binding affinity prediction. [PDF]

Bioinformatics
Sun X, Liu X, Huang J, Wu J, Sun Y, Jia J.   +5 more
europepmc   +1 more source

Placental crises: disruptive selection and maternal under‐investment as the foundations of mammalian placental evolution and dysfunction

Biological Reviews, EarlyView.
ABSTRACT Among the vertebrates, mammals are notable for the dominance of live birth and placental nutrition. The structural diversity of the mammalian placenta is remarkable, despite sharing a single common ancestor and conserved physiological functions.
Davis Laundon, Neil J. Gostling, Ian G. Reddin, Bram G. Sengers, Pascale Chavatte‐Palmer, Rohan M. Lewis   +5 more
wiley   +1 more source

An integrative bioinformatics framework for functional annotation and prioritization of hypothetical proteins in Bacillus thuringiensis relevant to biological pest control. [PDF]

Braz J Microbiol
Machado V, Kwecko MR, Dos Reis MAP, Galian J.   +3 more
europepmc   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Rethinking bioinformatics expertise in the era of artificial intelligence. [PDF]

NPJ Digit Med
Wen Bin Goh W, Polster A, Wong L, Cvijovic M.   +3 more
europepmc   +1 more source

Ensemble‐based soil liquefaction assessment: Leveraging CPT data for enhanced predictions

Civil Engineering Design, Volume 7, Issue 1, Page 23-35, March 2025.
Abstract This study focuses on predicting soil liquefaction, a critical phenomenon that can significantly impact the stability and safety of structures during seismic events. Accurate liquefaction assessment is vital for geotechnical engineering, as it informs the design and mitigation strategies needed to safeguard infrastructure and reduce the risk ...
Arsham Moayedi Far, Masoud Zare
wiley   +1 more source

Improving knowledge of metagenome-assembled genomes (MAGs) through bioinformatics and article annotation. [PDF]

J Microbiol Biol Educ
Whitham JM, Goller CC.
europepmc   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, EarlyView.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source