Results 101 to 110 of about 188,569 (212)

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

Animal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan, Ruiguang Huang, Shuqiong Cao, Luxia Pan, Wenkai Zhang, Wujun Jiang, Zhiyong Liu   +6 more
wiley   +1 more source

PEARL: integrative multi-omics classification and omics feature discovery via deep graph learning. [PDF]

Bioinformatics
Zhao Q, Du J, Zhou M, Wang XW, Sun Q, Chen C.   +5 more
europepmc   +1 more source

Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Accelerated long-read variant calling with Clair3 for whole-genome sequencing. [PDF]

Bioinformatics
Zheng Z, He M, Yu X, Li J, Chen L, Wong AOK, Zhang J, Zhou Y, Luo R.   +8 more
europepmc   +1 more source

Advancing Soybean Improvement: Multi-Omics Strategies, Cutting-Edge Techniques, and Bioinformatics Innovations. [PDF]

Plants (Basel)
Samanfar B.
europepmc   +1 more source

<i>OncoSolidDB</i>: An Oncology-Focused Curated Database of Ligand-Target Interactions for Precision Medicine Across Major Solid Cancers. [PDF]

Cancers (Basel)
Khamessi O, Mahjoub R, Mahjoub G, Ghedira K.   +3 more
europepmc   +1 more source

BindPred: a framework for predicting protein-protein binding affinity from language model embeddings. [PDF]

Bioinformatics
Piao H, Boorla VS, Santra S, Maranas CD.
europepmc   +1 more source

Inferring the qualities of protein-RNA models with graph transformers. [PDF]

Bioinformatics
Siciliano AJ, Bao Y, Shrestha B, Wang Z.
europepmc   +1 more source

Ancient hybridization and phylogenetic discordance: Exploring evolutionary complexity in Asteraceae

Applications in Plant Sciences, EarlyView.
Abstract Premise Conflicting phylogenetic signals are common in plant phylogenomics and often reflect evolutionary histories shaped by processes like hybridization, incomplete lineage sorting, and whole‐genome duplication (WGD). We aimed to identify and assess these complex processes in the hyper‐diverse family Asteraceae to offer insight into the ...
Paige A. Ellestad, Erika R. Moore‐Pollard, Carolina M. Siniscalchi, Ramhari Thapa, Linda E. Watson, J. Mauricio Bonifacino, Jennifer R. Mandel   +6 more
wiley   +1 more source

Reframing bioinformatics capacity development in Africa: from training supply to research-driven demand. [PDF]

J Community Genet
Hussein J, Myovela H.
europepmc   +1 more source