Results 141 to 150 of about 4,213,444 (308)
Computational Molecular Biology [PDF]
, 1996 Computational Biology is a fairly new subject that arose in response to the computational problems posed by the analysis and the processing of biomolecular sequence and structure data.
Lenhof, H., Mutzel, P., Vingron, M.
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, 2021 Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, February, 2021Cataloged from the official PDF of thesis. "February 2021."Includes bibliographical references.Tumor progression, from the single mutated cell
Marjanovic, Nemanja.
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FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
, 2012 Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2012.This electronic version was submitted by the student author.
Guo, Yuchun
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FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Getting started in computational biology
, 2018 These are slides from Lecture 2 of the course CMSE 491: Bioinformatics and Computational Biology taught in Spring 2018 at Michigan State University on Monday, January 2. This lecture covers the following topics and is meant to provide a "getting started"
Krishnan, Arjun (5140040) +1 more
core +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Machine learning for understanding protein sequence and structure
, 2020 Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, February, 2020Cataloged from student-submitted PDF of thesis.Includes bibliographical references (pages 183-200).Proteins are the fundamental building ...
Bepler, Tristan(Tristan Wendland)
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Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source