Results 121 to 130 of about 4,213,444 (308)
Computational insights into the ecology of the human microbiota
, 2016 Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, February 2016.Cataloged from PDF version of thesis.Includes bibliographical references (pages 99-110).The vast community of microbes that inhabit the human ...
Smillie, Christopher Scott
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RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Computational Systems Biology: German/Russian Network of Computational Systems Biology
, 2010 Hofestädt R, Kolchanov N, eds. Computational Systems Biology: German/Russian Network of Computational Systems Biology.
Hofestädt, Ralf, Kolchanov, Nikolay
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Correction: The Opponent Channel Population Code of Sound Location Is an Efficient Representation of Natural Binaural Sounds. [PDF]
PLoS Computational Biology, 2015 PLOS Computational Biology Staff
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Advancements and Challenges in Computational Biology
PLoS Computational Biology, 2015 Computational biology has soared from being an auxiliary discipline to being a crucial element for progress in practically all aspects of the biological sciences. In this annual Editorial, I would like to step back, consider significant computational biology advances of the last decade, and reflect on some key challenges ahead.
openaire +5 more sources
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Editorial Note by Prof. Achuth Sankar Nair
, 2014 I am very much pleased to release this issue of IJCB with some very good research works as discussed aforementioned. With a detailed view about the cutting edge computational techniques being applied to solve the mystery of biology, these works published
Nair, Achuth Sankar; Kerala University
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source