Results 121 to 130 of about 3,347,103 (312)
, 2009 It is impossible to pinpoint the exact moment at which computational biology became a discipline of its own, but one could say that it was in 1997 when the society of computational biology was formed.
Michelle LaBrunda, Andrew LaBrunda
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Computational biology and high-performance computing
Communications of the ACM, 2004 Understanding evolution and the basic structure and function of proteins are two grand challenge problems in biology that can be solved only through the use of high-performance computing.
openaire +3 more sources
Computational Biology and High Performance Computing 2000 [PDF]
, 2000 The pace of extraordinary advances in molecular biology has accelerated in the past decade due in large part to discoveries coming from genome projects on human and model organisms.
Simon, Horst D. +7 more
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Correction: The Opponent Channel Population Code of Sound Location Is an Efficient Representation of Natural Binaural Sounds. [PDF]
PLoS Computational Biology, 2015 PLOS Computational Biology Staff
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Advancements and Challenges in Computational Biology
PLoS Computational Biology, 2015 Computational biology has soared from being an auxiliary discipline to being a crucial element for progress in practically all aspects of the biological sciences. In this annual Editorial, I would like to step back, consider significant computational biology advances of the last decade, and reflect on some key challenges ahead.
openaire +5 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Computational Structural Analysis of C-Terminal Residues of Proteins Containing Transmembrane Regions [PDF]
, 2015 For the past few years, the numbers of transmembrane protein structures in Protein Data Bank have been increased substantially. It is of interest to analyze the terminal residues of transmembrane proteins by using computational approaches.
KM, Saravanan; Centre of Excellence in Bioinformatics School of Biotechnology Madurai Kamaraj University Madurai 625 021 Tamilnadu India +1 more
core +2 more sources