Results 101 to 110 of about 502,236 (314)

Correction: Correction: Quantifying microbial interactions based on compositional data using an iterative approach for solving generalized Lotka-Volterra equations.

open access: yesPLoS Computational Biology
[This corrects the article DOI: 10.1371/journal.pcbi.1013876.].
PLOS Computational Biology Staff
doaj   +1 more source

Computational Biology Approach for Therapeutic Intervention of Alexander Disease by Post Transcriptional Gene Silencing

open access: yes, 2017
Alexander disease (AxD) primarily affects the white matter of the central nervous system (CNS). It is an astrogliopathy in which Astroglial cells involved in maintenance homeostasis and providing defence to the brain are affected.
Sahrawat, Tammanna Ravee; Centre for Systems Biology and Bioinformatics, UIEAST, Panjab University, Chandigarh
core  

Guest Editorial for the ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

open access: yes, 2019
It is our great pleasure to present this special issue of the IEEE/ACM Transactions on Computational Biology and Bioinformatics. The special issue includes six papers, which were invited from the ACM Conference on Bioinformatics, Computational Biology ...
Pozzi, Giuseppe   +2 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

A Novel DNA Sequence Compression Method Based on Chaos Game Representation

open access: yes, 2014
Unique signature images derived out of Chaos Game Representation of bio-sequences is an area of research that has been confined to pattern recognition applications.
Arun, K S; Department of Computational Biology and Bioinformatics, University of Kerala, India   +2 more
core  

Bioinformatics and Computational Biology in Poland

open access: yesPLoS Computational Biology, 2013
The series of articles in PLOS Computational Biology on the development of bioinformatics activities in various countries, e.g., China [1], Australia [2], and Singapore [3], and the formation and successful development of the Polish Bioinformatics Society over the last five years, have inspired us to present a personal perspective on the advances of ...
Janusz M. Bujnicki, Jerzy Tiuryn
openaire   +4 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

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