Results 101 to 110 of about 3,347,103 (312)
Computational systems biology /
, 2014 This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as ...
Kriete, Andres., Eils, Roland.
core
Correction: Success-efficient/failure-safe strategy for hierarchical reinforcement motor learning.
PLoS Computational Biology[This corrects the article DOI: 10.1371/journal.pcbi.1013089.].
PLOS Computational Biology Staff
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Varieties of Noise: Analogical Reasoning in Synthetic Biology [PDF]
, 2013 The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks.
Knuuttila, Tarja, Loettgers, Andrea
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Artificial life meets computational creativity? [PDF]
, 2009 I review the history of work in Artificial Life on the problem of the open-ended evolutionary growth of complexity in computational worlds.
McMullin, Barry
core +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Correction: Random Wiring, Ganglion Cell Mosaics, and the Functional Architecture of the Visual Cortex. [PDF]
PLoS Computational Biology, 2016 PLOS Computational Biology Staff
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source