Results 81 to 90 of about 502,236 (314)
Correction: Direct Correlation between Motile Behavior and Protein Abundance in Single Cells. [PDF]
PLoS Computational Biology, 2016 [This corrects the article DOI: 10.1371/journal.pcbi.1005041.].
PLOS Computational Biology Staff
doaj +1 more source
Computational biology: plus c'est la même chose, plus ça change [PDF]
, 2013 A report on the joint 19th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB)/10th Annual European Conference on Computational Biology (ECCB) meetings and the 7th International Society for Computational Biology Student ...
Huttenhower, Curtis
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MapReduce in Computational Biology - A Synopsis [PDF]
, 2017 In the past 20 years, the Life Sciences have witnessed a paradigm shift in the way research is performed. Indeed, the computational part of biological and clinical studies has become central or is becoming so. Correspondingly, the amount of data that one needs to process, compare and analyze, has experienced an exponential growth.
CATTANEO, Giuseppe +5 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Guest Editorial: Computational Biology
, 2014 Computational biology has been used to help sequence the human genome, create accurate models of the human brain, and assist in modeling biological systems. With the availability of massive datasets, it has also become possible to study different systems
Gupta, Pushpendra K; Ch. Charan Singh University Meerut, UP India
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Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
, 2014 Biological data exists in several layers from genome sequence to networks and beyond. Information that comes from environment passes through layers of viscosity within organisms and is transformed into an output released back into the environment.
Dhar, Pawan K; Centre for Systems and Synthetic Biology, Department of Computational Biology and Bioinformatics, University of Kerala, Trivandrum, Kerala
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Automating fault tolerance in high-performance computational biological jobs using multi-agent approaches [PDF]
, 2014 Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Varghese, Blesson +2 more
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Limits of computational biology
In Silico Biology, 2015 Abstract Are we close to a complete inventory of living processes so that we might expect in the near future to reproduce every essential aspect necessary for life? Or are there mechanisms and processes in cells and organisms that are presently inaccessible to us?
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