Results 61 to 70 of about 460,440 (266)
Correction: When Optimal Feedback Control Is Not Enough: Feedforward Strategies Are Required for Optimal Control with Active Sensing. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1005190.].
PLOS Computational Biology Staff
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Correction: Improving Collective Estimations Using Resistance to Social Influence. [PDF]
PLoS Computational Biology, 2016 [This corrects the article DOI: 10.1371/journal.pcbi.1004594.].
PLOS Computational Biology Staff
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Computational Biology in Brazil
PLoS Computational Biology, 2007 At the request of the PLoS Computational Biology Editor-in-Chief, I agreed to write about computational biology in Brazil (see author information in Box 1). That meant describing: a) the history of the field in our country (short as the history of the field itself is short); b) the current state of the field in Brazil; c) the influence of computational
openaire +4 more sources
Correction: Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial. [PDF]
PLoS Computational Biology, 2016 [This corrects the article DOI: 10.1371/journal.pcbi.1003973.].
PLOS Computational Biology Staff
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Correction: Ten simple rules for structuring papers. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1005619.].
PLOS Computational Biology Staff
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source