Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
In-silico design of an Epitope-based peptide vaccine: A Computational Biology Approach [PDF]
, 2016 Lymphocytic choriomeningitis, is a rodent-borne viral infectious disease caused by Lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.
Sahrawat, Tammanna Ravee; Centre for Systems Biology and Bioinformatics, UIEAST, Panjab University, Chandigarh
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Correction: A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1004919.].
PLOS Computational Biology Staff
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Computational methods for analyzing and modeling gene regulation and 3D genome organization
, 2021 Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, February, 2021Cataloged from the official PDF of thesis.Includes bibliographical references (pages 261-281).Biological processes from differentiation to ...
Belyaeva, Anastasiya.
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Editorial : integrative computational systems biology approaches in immunology and medicine [PDF]
, 2019 Editorial on the Research Topic "Integrative Computational Systems Biology Approaches in Immunology and ...
Hernandez-Vargas, Esteban Abelardo +25 more
core +1 more source
Correction: Emergence of Slow-Switching Assemblies in Structured Neuronal Networks. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1004196.].
PLOS Computational Biology Staff
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
The computational stance in biology [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2019 The goal of this article is to call attention to, and to express caution about, the extensive use of computation as an explanatory concept in contemporary biology. Inspired by Dennett's ‘intentional stance’ in the philosophy of mind, I suggest that a ‘computational stance’ can be a productive approach to evaluating the value of computational concepts ...
openaire +2 more sources
Correction: When Optimal Feedback Control Is Not Enough: Feedforward Strategies Are Required for Optimal Control with Active Sensing. [PDF]
PLoS Computational Biology, 2017 [This corrects the article DOI: 10.1371/journal.pcbi.1005190.].
PLOS Computational Biology Staff
doaj +1 more source