Results 71 to 80 of about 3,347,103 (312)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Metacognition: computation, biology and function [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2012
Many complex systems maintain a self-referential check and balance. In animals, such reflective monitoring and control processes have been grouped under the rubric of metacognition. In this introductory article to a Theme Issue on metacognition, we review recent and rapidly progressing developments from neuroscience, cognitive psychology, computer ...
Fleming, S., Dolan, R. ; https://orcid.org/0000-0001-9356-761X, Frith, C.   +2 more
openaire   +2 more sources

Reproducible computational biology experiments with SED-ML-the Simulation Experiment Description Markup Language [PDF]

, 2011
The increasing use of computational simulation experiments to inform modern biological research creates new challenges to annotate, archive, share and reproduce such experiments.
Ion I Moraru, Richard Adams, Andrew K Miller, Sven Sahle, Sahle, Sven, Snoep, Jacky L, Moraru, Ion I, Waltemath, Dagmar, Miller, Andrew K., Miller, Andrew K, Frank T Bergmann, Nickerson, David, Adams, Richard, Le Novère, Nicolas, Kolpakov, Fedor, Bergmann, Frank T, David Nickerson, Fedor Kolpakov, Michael Hucka, Dagmar Waltemath, Snoep, Jacky L., Jacky L Snoep, Moraru, Ion I., Nicolas Le Novère, Hucka, Michael, Bergmann, Frank T.   +25 more
core   +1 more source

Correction: Ten simple rules for structuring papers. [PDF]

PLoS Computational Biology, 2017
[This corrects the article DOI: 10.1371/journal.pcbi.1005619.].
PLOS Computational Biology Staff
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

A Novel DNA Sequence Compression Method Based on Chaos Game Representation [PDF]

, 2014
Unique signature images derived out of Chaos Game Representation of bio-sequences is an area of research that has been confined to pattern recognition applications.
Arun, K S; Department of Computational Biology and Bioinformatics, University of Kerala, India, Oommen, Oommen V; Department of Computational Biology and Bioinformatics, University of Kerala, India, Nair, Achuthsankar S.; Department of Computational Biology and Bioinformatics, University of Kerala, India   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Limits of computational biology

In Silico Biology, 2015
Abstract Are we close to a complete inventory of living processes so that we might expect in the near future to reproduce every essential aspect necessary for life? Or are there mechanisms and processes in cells and organisms that are presently inaccessible to us?
openaire   +3 more sources

Correction: Correction: Quantifying microbial interactions based on compositional data using an iterative approach for solving generalized Lotka-Volterra equations.

PLoS Computational Biology
[This corrects the article DOI: 10.1371/journal.pcbi.1013876.].
PLOS Computational Biology Staff
doaj   +1 more source

Correction: Mathematical modeling of the molecular switch of TNFR1-mediated signaling pathways applying Petri net formalism and in silico knockout analysis.

PLoS Computational Biology, 2023
[This corrects the article DOI: 10.1371/journal.pcbi.1010383.].
PLOS Computational Biology Staff
doaj   +1 more source