Results 71 to 80 of about 993,851 (283)

Correction: Large-Scale Off-Target Identification Using Fast and Accurate Dual Regularized One-Class Collaborative Filtering and Its Application to Drug Repurposing. [PDF]

PLoS Computational Biology, 2017
[This corrects the article DOI: 10.1371/journal.pcbi.1005135.].
PLOS Computational Biology Staff
doaj   +1 more source

GpABC: a Julia package for approximate Bayesian computation with Gaussian process emulation [PDF]

, 2019
Motivation Approximate Bayesian computation (ABC) is an important framework within which to infer the structure and parameters of a systems biology model.
Hameed, Tara, He, Fei, Ish-Horowicz, Jonathan, Kleijn, Istvan, Roesch, Elisabeth, Stumpf, Michael P H, Tankhilevich, Evgeny   +6 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Erratum: Notice of Republication: Simulating Cortical Development as a Self Constructing Process: A Novel Multi-Scale Approach Combining Molecular and Physical Aspects.

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1003173.].
PLOS Computational Biology Staff
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Correction: clusterExperiment and RSEC: A Bioconductor package and framework for clustering of single-cell and other large gene expression datasets.

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1006378.].
PLOS Computational Biology Staff
doaj   +1 more source

DNA meets the SVD [PDF]

, 2008
This paper introduces an important area of computational cell biology where complex, publicly available genomic data is being examined by linear algebra methods, with the aim of revealing biological and medical ...
Grindrod, Peter, Higham, Desmond J., Kalna, Gabriela, Spence, Alistair, Stoyanov, Zhivko, Vass, J. Keith   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Correction: A model for the origin and development of visual orientation selectivity.

PLoS Computational Biology, 2019
[This corrects the article DOI: 10.1371/journal.pcbi.1007254.].
PLOS Computational Biology Staff
doaj   +1 more source