Results 91 to 100 of about 4,213,444 (308)

Computational Inference in Systems Biology [PDF]

, 2015
Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high. Aimed at reducing this cost, new concepts using gradient matching have been proposed.
Benn Macdonald, Dirk Husmeier
openaire   +1 more source

Computational systems biology /

, 2014
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as ...
Kriete, Andres., Eils, Roland.
core  

Guest Editorial for the ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

, 2019
It is our great pleasure to present this special issue of the IEEE/ACM Transactions on Computational Biology and Bioinformatics. The special issue includes six papers, which were invited from the ACM Conference on Bioinformatics, Computational Biology ...
Pozzi, Giuseppe, Kahveci, Tamer, Shehu, Amarda   +2 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus [PDF]

, 2015
Speed is of the essence in combating Ebola; thus, computational approaches should form a significant component of Ebola research. As for the development of any modern drug, computational biology is uniquely positioned to contribute through comparative ...
Linial, Michal, Lengauer Thomas, Hide, W., Bonnie Berger, Pardis Sabeti, Rost Burkhard, Lengauer, T., Rost, Burkhard, Burkhard Rost, Thomas Lengauer, Karp, Peter D., Kovats Diane, Berger, Bonnie, Kovats, D., Kovats, Diane, Karp, P.D., Lengauer, Thomas, Sabeti Pardis, Linial, M., Karp Peter D., Winston Hide, Sabeti, Pardis, Sabeti, P., Berger, B., Rost, B., Hide Winston, Peter D. Karp, Berger Bonnie, Hide, Winston, Michal Linial, Karp, P., Diane Kovats, Linial Michal, Karp, Peter D.;Berger, Bonnie;Kovats, Diane;Lengauer, Thomas;Linial, Michal;Sabeti, Pardis;Hide, Winston;Rost, Burkhard   +33 more
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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Bioinformatics and Computational Biology in Poland

PLoS Computational Biology, 2013
The series of articles in PLOS Computational Biology on the development of bioinformatics activities in various countries, e.g., China [1], Australia [2], and Singapore [3], and the formation and successful development of the Polish Bioinformatics Society over the last five years, have inspired us to present a personal perspective on the advances of ...
Janusz M. Bujnicki, Jerzy Tiuryn
openaire   +4 more sources

MapReduce in Computational Biology - A Synopsis [PDF]

, 2017
In the past 20 years, the Life Sciences have witnessed a paradigm shift in the way research is performed. Indeed, the computational part of biological and clinical studies has become central or is becoming so. Correspondingly, the amount of data that one needs to process, compare and analyze, has experienced an exponential growth.
CATTANEO, Giuseppe, GIANCARLO, Raffaele, PIOTTO PIOTTO, Stefano, Petrillo, Umberto Ferraro, ROSCIGNO, GIANLUCA, DI BIASI, LUIGI   +5 more
openaire   +3 more sources

Computational design of orthogonal antiparallel homodimeric coiled coils

, 2014
Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2014.Cataloged from PDF version of thesis.Includes bibliographical references.Living cells integrate a vast array of protein-protein interactions (PPIs) to ...
Negron, Christopher
core  

Computational Biology [PDF]

, 2010
Computational biology is an interdisciplinary field that applies the techniques of computer science, applied mathematics, and statistics to address biological questions.
Greenberg, Harvey, Holder, Allen
core   +1 more source