Results 111 to 120 of about 3,347,103 (312)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Topics in Computational and Systems Biology

open access: yes, 2007
This is a seminar based on research literature. Papers covered are selected to illustrate important problems and approaches in the field of computational and systems biology, and provide students a framework from which to evaluate new developments.
Burge, Christopher
core  

Guest Editorial for the ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics

open access: yes, 2019
It is our great pleasure to present this special issue of the IEEE/ACM Transactions on Computational Biology and Bioinformatics. The special issue includes six papers, which were invited from the ACM Conference on Bioinformatics, Computational Biology ...
Pozzi, Giuseppe   +2 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Editorial Note by Prof. Achuth Sankar Nair

open access: yes, 2014
I am very much pleased to release this issue of IJCB with some very good research works as discussed aforementioned. With a detailed view about the cutting edge computational techniques being applied to solve the mystery of biology, these works published
Nair, Achuth Sankar; Kerala University
core  

Automating fault tolerance in high-performance computational biological jobs using multi-agent approaches [PDF]

open access: yes, 2014
Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Varghese, Blesson   +2 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Modelling and Computational Sequence Analysis of a Bacteriocin Isolated from Bacillus licheniformis strain BTHT8 [PDF]

open access: yes, 2018
Bacteriocins are ribosomally synthesized antimicrobial peptides displaying different mode of action. Non pathogenic Bacillus licheniformis are usually associated with plants and produce several bacteriocins.
Bhat, Sarita G; Cochin University of Science and Technology
core   +1 more source

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