Results 101 to 110 of about 449,948 (311)
Special Issue on Reconfiguration Problems
Algorithms, 2018 The study of reconfiguration problems has grown into a field of its own. The basic idea is to consider the scenario of moving from one given (feasible) solution to another, maintaining feasibility for all intermediate solutions.
Faisal Abu-Khzam +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Functional impact of multi-omic interactions in lung cancer
Frontiers in GeneticsLung tumors are a leading cause of cancer-related death worldwide. Lung cancers are highly heterogeneous on their phenotypes, both at the cellular and molecular levels.
Miguel Ángel Díaz-Campos +5 more
doaj +1 more source
On the Complexity of Target Set Selection in Simple Geometric Networks [PDF]
Discrete Mathematics & Theoretical Computer ScienceWe study the following model of disease spread in a social network. At first, all individuals are either infected or healthy. Next, in discrete rounds, the disease spreads in the network from infected to healthy individuals such that a healthy individual
Michal Dvořák +2 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Common Agency and Computational Complexity: Theory and Experimental Evidence [PDF]
In a common agency game, several principals try to influence the behavior of an agent. Common agency games typically have multiple equilibria. One class of equilibria, called truthful, has been identified by Bernheim and Whinston and has found widespread
Prat, A., Kirchsteiger, G.
core +1 more source
Depth lower bounds in Stabbing Planes for combinatorial principles [PDF]
Logical Methods in Computer ScienceStabbing Planes (also known as Branch and Cut) is a proof system introduced very recently which, informally speaking, extends the DPLL method by branching on integer linear inequalities instead of single variables.
Stefan Dantchev +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
The Computational Difficulty of Bribery in Qualitative Coalitional Games [PDF]
Qualitative coalitional games (QCG) are representations of coalitional games in which self interested agents, each with their own individual goals, group together in order to achieve a set of goals which satisfy all the agents within that group.
Andrew Dowell +2 more
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