Results 121 to 130 of about 3,355,376 (309)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The Computational Difficulty of Bribery in Qualitative Coalitional Games [PDF]

Qualitative coalitional games (QCG) are representations of coalitional games in which self interested agents, each with their own individual goals, group together in order to achieve a set of goals which satisfy all the agents within that group.
Andrew Dowell, Michael Wooldridge, Peter McBurney   +2 more
core  

Master Regulators of Signaling Pathways: An Application to the Analysis of Gene Regulation in Breast Cancer

Frontiers in Genetics, 2019
Analysis of gene regulatory networks allows the identification of master transcriptional factors that control specific groups of genes. In this work, we inferred a gene regulatory network from a large dataset of breast cancer samples to identify the ...
Diana Tapia-Carrillo, Diana Tapia-Carrillo, Hugo Tovar, Tadeo Enrique Velazquez-Caldelas, Enrique Hernandez-Lemus, Enrique Hernandez-Lemus   +5 more
doaj   +1 more source

Computational complexity drives sustained deliberation. [PDF]

Nat Neurosci, 2023
Hong T, Stauffer WR.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Quantum Computational Complexity of Matrix Functions

PRX Quantum
We investigate the dividing line between classical and quantum computational power in estimating properties of matrix functions. More precisely, we study the computational complexity of two primitive problems: given a function f and a Hermitian matrix A,
Santiago Cifuentes, Samson Wang, Thais L. Silva, Mario Berta, Leandro Aolita   +4 more
doaj   +1 more source

Computational Complexity and Its Influence on Predictive Capabilities of Machine Learning Models for Concrete Mix Design. [PDF]

Materials (Basel), 2023
Ziolkowski P.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Computational Complexity in the Design of Voting Rules [PDF]

This paper discusses an aspect of computational complexity in social choice theory. We consider the problem of designing voting rules, which is formulated in terms of simple games.
Koji Takamiya, Akira Tanaka
core  

Computational complexity, algorithmic scope, and evolution

Journal of Physics: Complexity
Biological systems are widely regarded as performing computations. It is much less clear, however, what exactly is computed and how biological computation fits within the framework of standard computer science.
Leonhard Sidl, Maximilian Faissner, Manuel Uhlir, Cristian A Velandia-Huerto, Maria Waldl, Hua-Ting Yao, Ivo L Hofacker, Peter F Stadler   +7 more
doaj   +1 more source