Results 111 to 120 of about 449,948 (311)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

On the complexity of MMSNP [PDF]

open access: yes, 2012
International audienceMonotone monadic strict NP (MMSNP) is a class of computational problems that is closely related to the class of constraint satisfaction problems for constraint languages over finite domains. It is known that one of those classes has
Feder, Tomas   +2 more
core  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Quantum Computational Complexity of Matrix Functions

open access: yesPRX Quantum
We investigate the dividing line between classical and quantum computational power in estimating properties of matrix functions. More precisely, we study the computational complexity of two primitive problems: given a function f and a Hermitian matrix A,
Santiago Cifuentes   +4 more
doaj   +1 more source

Master Regulators of Signaling Pathways: An Application to the Analysis of Gene Regulation in Breast Cancer

open access: yesFrontiers in Genetics, 2019
Analysis of gene regulatory networks allows the identification of master transcriptional factors that control specific groups of genes. In this work, we inferred a gene regulatory network from a large dataset of breast cancer samples to identify the ...
Diana Tapia-Carrillo   +5 more
doaj   +1 more source

Computability and Complexity in Analysis.

open access: yesJ. Univers. Comput. Sci., 2009
Computability and Complexity in ...
Brattka,Vasco   +2 more
openaire   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Computational Complexity in the Design of Voting Rules [PDF]

open access: yes
This paper discusses an aspect of computational complexity in social choice theory. We consider the problem of designing voting rules, which is formulated in terms of simple games.
Koji Takamiya, Akira Tanaka
core  

The complexity of explicit construction problems [PDF]

open access: yes
Explicit constructions of pseudorandom objects play a central role in theoretical computer science. Unfortunately, for many properties of interest, while a randomly chosen object would satisfy them with high probability, deterministically constructing ...
Ren, Hanlin
core   +2 more sources

07411 Executive Summary – Algebraic Methods in Computational Complexity [PDF]

open access: yes, 2008
The seminar brought together almost 50 researchers covering a wide spectrum of complexity theory. The focus on algebraic methods showed once again the great importance of algebraic techniques for theoretical computer science. We had almost 30 talks of
Agrawal, Manindra   +3 more
core   +1 more source

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