Results 111 to 120 of about 5,239,116 (369)

Optical Computing and Computational Complexity

, 2006
This work concerns the computational complexity of a model of computation that is inspired by optical computers. The model is called the continuous space machine and operates in discrete timesteps over a number of two-dimensional images of fixed size and arbitrary spatial resolution.
openaire   +2 more sources

Information complexity is computable

, 2015
30 ...
Braverman, Mark, Schneider, Jon
openaire   +5 more sources

Computability and Complexity of Unconventional Computing Devices [PDF]

, 2018
We discuss some claims that certain UCOMP devices can perform hypercomputation (compute Turing-uncomputable functions) or perform super-Turing computation (solve NP-complete problems in polynomial time). We discover that all these claims rely on the provision of one or more unphysical resources.
Susan Stepney, Göran Wendin, Hajo Broersma   +2 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Depth lower bounds in Stabbing Planes for combinatorial principles [PDF]

Logical Methods in Computer Science
Stabbing Planes (also known as Branch and Cut) is a proof system introduced very recently which, informally speaking, extends the DPLL method by branching on integer linear inequalities instead of single variables.
Stefan Dantchev, Nicola Galesi, Abdul Ghani, Barnaby Martin   +3 more
doaj   +1 more source

Computational Complexity Evaluation of Neural Network Applications in Signal Processing

arXiv.org, 2022
Pedro J. Freire, S. Srivallapanondh, A. Napoli, J. Prilepsky, S. Turitsyn   +4 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Functional impact of multi-omic interactions in lung cancer

Frontiers in Genetics
Lung tumors are a leading cause of cancer-related death worldwide. Lung cancers are highly heterogeneous on their phenotypes, both at the cellular and molecular levels.
Miguel Ángel Díaz-Campos, Jorge Vasquez-Arriaga, Soledad Ochoa, Soledad Ochoa, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +5 more
doaj   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source