Results 31 to 40 of about 315,143 (255)
Depth, Highness and DNR degrees [PDF]
Discrete Mathematics & Theoretical Computer Science, 2017 We study Bennett deep sequences in the context of recursion theory; in particular we investigate the notions of O(1)-deepK, O(1)-deepC , order-deep K and order-deep C sequences. Our main results are that Martin-Loef random sets are not order-deepC , that
Philippe Moser, Frank Stephan
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An overview on polynomial approximation of NP-hard problems [PDF]
Yugoslav Journal of Operations Research, 2009 The fact that polynomial time algorithm is very unlikely to be devised for an optimal solving of the NP-hard problems strongly motivates both the researchers and the practitioners to try to solve such problems heuristically, by making a trade-off between
Paschos Vangelis Th.
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Lower Bound on Weights of Large Degree Threshold Functions [PDF]
Logical Methods in Computer Science, 2013 An integer polynomial $p$ of $n$ variables is called a \emph{threshold gate} for a Boolean function $f$ of $n$ variables if for all $x \in \zoon$ $f(x)=1$ if and only if $p(x)\geq 0$.
Vladimir V. Podolskii
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Complexity theory for spaces of integrable functions [PDF]
Logical Methods in Computer Science, 2017 This paper investigates second-order representations in the sense of Kawamura and Cook for spaces of integrable functions that regularly show up in analysis. It builds upon prior work about the space of continuous functions on the unit interval: Kawamura
Florian Steinberg
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Data Integration Challenges for Machine Learning in Precision Medicine
Frontiers in Medicine, 2022 A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on different databases about the molecular and environmental origins of disease, into analytic frameworks, allowing the development of individualized, context ...
Mireya Martínez-García +2 more
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source