Results 41 to 50 of about 1,450,191 (282)
Computational Complexity and Phase Transitions
, 2000 Phase transitions in combinatorial problems have recently been shown to be useful in locating "hard" instances of combinatorial problems. The connection between computational complexity and the existence of phase transitions has been addressed in ...
Istrate, Gabriel
core +1 more source
Lower Bound on Weights of Large Degree Threshold Functions [PDF]
Logical Methods in Computer Science, 2013 An integer polynomial $p$ of $n$ variables is called a \emph{threshold gate} for a Boolean function $f$ of $n$ variables if for all $x \in \zoon$ $f(x)=1$ if and only if $p(x)\geq 0$.
Vladimir V. Podolskii
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Complexity theory for spaces of integrable functions [PDF]
Logical Methods in Computer Science, 2017 This paper investigates second-order representations in the sense of Kawamura and Cook for spaces of integrable functions that regularly show up in analysis. It builds upon prior work about the space of continuous functions on the unit interval: Kawamura
Florian Steinberg
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Computational Complexity of Certifying Restricted Isometry Property [PDF]
, 2014 Given a matrix $A$ with $n$ rows, a number ...
Natarajan, Abhiram, Wu, Yi
core +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Efficient inner product arguments and their applications in range proofs
IET Information Security, 2023 Inner product arguments allow a prover to prove that the inner product of two committed vectors equals a public scalar. They are used to reduce the complexity of many cryptographic primitives, such as range proofs.
Zibo Zhou +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Data Integration Challenges for Machine Learning in Precision Medicine
Frontiers in Medicine, 2022 A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on different databases about the molecular and environmental origins of disease, into analytic frameworks, allowing the development of individualized, context ...
Mireya Martínez-García +2 more
doaj +1 more source