Results 51 to 60 of about 1,450,191 (282)
On physical problems that are slightly more difficult than QMA
, 2014 We study the complexity of computational problems from quantum physics. Typically, they are studied using the complexity class QMA (quantum counterpart of NP) but some natural computational problems appear to be slightly harder than QMA. We introduce new
Ambainis, Andris
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in ImmunologyBreast cancer, characterized by its complexity and diversity, presents significant challenges in understanding its underlying biology. In this study, we employed gene co-expression network analysis to investigate the gene composition and functional ...
Tadeo Enrique Velazquez-Caldelas +3 more
doaj +1 more source
On computational complexity of Set Automata
, 2017 We consider a computational model which is known as set automata. The set automata are one-way finite automata with an additional storage---the set. There are two kinds of set automata---the deterministic and the nondeterministic ones.
Rubtsov, Alexander A. +1 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Computational Creativity and Aesthetics with Algorithmic Information Theory
Entropy, 2021 We build an analysis based on the Algorithmic Information Theory of computational creativity and extend it to revisit computational aesthetics, thereby, improving on the existing efforts of its formulation.
Tiasa Mondol, Daniel G. Brown
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Fourier spectra of measures associated with algorithmically random Brownian motion [PDF]
Logical Methods in Computer Science, 2014 In this paper we study the behaviour at infinity of the Fourier transform of Radon measures supported by the images of fractal sets under an algorithmically random Brownian motion.
Willem Louw Fouché +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Comorbidity patterns in cardiovascular diseases: the role of life-stage and socioeconomic status
Frontiers in Cardiovascular MedicineCardiovascular diseases stand as a prominent global cause of mortality, their intricate origins often entwined with comorbidities and multimorbid conditions.
Héctor A. Cruz-Ávila +5 more
doaj +1 more source