Results 51 to 60 of about 3,355,376 (309)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Why Philosophers Should Care About Computational Complexity [PDF]
, 2011 One might think that, once we know something is computable, how efficiently it can be computed is a practical question with little further philosophical importance. In this essay, I offer a detailed case that one would be wrong.
Scott Aaronson, Aaronson, Scott
core
Efficient inner product arguments and their applications in range proofs
IET Information Security, 2023 Inner product arguments allow a prover to prove that the inner product of two committed vectors equals a public scalar. They are used to reduce the complexity of many cryptographic primitives, such as range proofs.
Zibo Zhou +4 more
doaj +1 more source
COMPOSITIONALITY, COMPUTABILITY, AND COMPLEXITY
The Review of Symbolic Logic, 2020 AbstractThis paper starts from the observation that the standard arguments for compositionality are really arguments for the computability of semantics. Since computability does not entail compositionality, the question of what justifies compositionality recurs. The paper then elaborates on the idea of recursive semantics as corresponding to computable
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Diagrams-to-Dynamics (D2D): Exploring causal loop diagram leverage points under uncertainty
BMC MedicineBackground Causal loop diagrams (CLDs) are widely used in health and environmental research to represent hypothesized causal structures underlying complex problems.
Jeroen F. Uleman +6 more
doaj +1 more source
Depth, Highness and DNR degrees [PDF]
Discrete Mathematics & Theoretical Computer Science, 2017 We study Bennett deep sequences in the context of recursion theory; in particular we investigate the notions of O(1)-deepK, O(1)-deepC , order-deep K and order-deep C sequences. Our main results are that Martin-Loef random sets are not order-deepC , that
Philippe Moser, Frank Stephan
doaj +1 more source
Reversible computing and implicit computational complexity
Science of Computer Programming, 2022 Abstract We argue that there is a link between implicit computational complexity theory and reversible computation. We introduce inherently reversible programming languages which capture the complexity classes etime and . Furthermore, we discuss and analyze higher-order versions of our reversible programming languages.
openaire +4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Teaching Complexity and Its Practical Implications in Leadership Development Programs
, 2018 This article describes an advanced leadership seminar for senior managers and executives. The three module seminar describes how thoughtful leaders can learn to succeed even under conditions of extreme complexity. The first module describes complexity in
Hazy, James K
core +1 more source