Results 61 to 70 of about 449,948 (311)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

07411 Abstracts Collection – Algebraic Methods in Computational Complexity [PDF]

, 2008
From 07.10. to 12.10., the Dagstuhl Seminar 07411 ``Algebraic Methods in Computational Complexity'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current
Agrawal, Manindra, Buhrman, Harry, Thierauf, Thomas, Fortnow, Lance   +3 more
core   +1 more source

Reversible computing and implicit computational complexity

Science of Computer Programming, 2022
Abstract We argue that there is a link between implicit computational complexity theory and reversible computation. We introduce inherently reversible programming languages which capture the complexity classes etime and . Furthermore, we discuss and analyze higher-order versions of our reversible programming languages.
openaire   +3 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Coordinated inflammation and immune response transcriptional regulation in breast cancer molecular subtypes

Frontiers in Immunology
Breast cancer, characterized by its complexity and diversity, presents significant challenges in understanding its underlying biology. In this study, we employed gene co-expression network analysis to investigate the gene composition and functional ...
Tadeo Enrique Velazquez-Caldelas, Jose Maria Zamora-Fuentes, Enrique Hernandez-Lemus, Enrique Hernandez-Lemus   +3 more
doaj   +1 more source

Data Integration Challenges for Machine Learning in Precision Medicine

Frontiers in Medicine, 2022
A main goal of Precision Medicine is that of incorporating and integrating the vast corpora on different databases about the molecular and environmental origins of disease, into analytic frameworks, allowing the development of individualized, context ...
Mireya Martínez-García, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Empirical Risk Minimization for Probabilistic Grammars: Sample Complexity and Hardness of Learning [PDF]

, 2012
Probabilistic grammars are generative statistical models that are useful for compositional and sequential structures. They are used ubiquitously in computational linguistics.
Noah A. Smith, Smith, N. A., Shay B. Cohen, Cohen, S. B.   +3 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Computational Creativity and Aesthetics with Algorithmic Information Theory

Entropy, 2021
We build an analysis based on the Algorithmic Information Theory of computational creativity and extend it to revisit computational aesthetics, thereby, improving on the existing efforts of its formulation.
Tiasa Mondol, Daniel G. Brown
doaj   +1 more source