Results 71 to 80 of about 769,896 (315)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Scientific ReportsThis paper presents the co-design methods for a new hybrid load-bearing system as a strategy for advancing bio-based architecture. Timber and natural fiber polymer composites (NFPC) are combined into a hybrid system, offering opportunities to leverage ...
Rebeca Duque Estrada +5 more
doaj +1 more source
iScience, 2019 Summary: To overcome limited information on organic cathode materials for lithium-ion batteries, we studied the electrochemical redox properties of pyrenetetrone and its nitrogen-doped derivatives.
Chae Young Go +2 more
doaj +1 more source
Creating ecologically sound buildings by integrating ecology, architecture and computational design
People and Nature, 2023 Research is revealing an increasing number of positive effects of nature for humans. At the same time, biodiversity in cities, where most humans live, is often low or in decline. Tangible solutions are needed to increase urban biodiversity.
Wolfgang W. Weisser +14 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Synthesising computational design methods for a human-centred design framework [PDF]
, 2022 This paper presents models that identify two "cultures" of computational design practice. By reviewing the established culture of computational optimization efforts and contrasting it with the emerging work integrating human-factors into these ...
Loudon, Brian +2 more
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Quantum Chemistry Meets Machine Learning
CHIMIA, 2019 In this account, we demonstrate how statistical learning approaches can be leveraged across a range of different quantum chemical areas to transform the scaling, nature, and complexity of the problems that we are tackling.
Alberto Fabrizio +3 more
doaj +1 more source
Computational Design of Enzymes
Chemistry & Biology, 2008 The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving field (Röthlisberger et al., 2008; Jiang et al., 2008).
Sterner, Reinhard +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source