Results 51 to 60 of about 4,861,317 (256)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Computational efficiency of 512bit.
, 2021 Computational efficiency of 512bit.
Hasan Naji Hasan Abdullah (11604045) +3 more
core +1 more source
Energies, 2022 In the current scenario, where environmental concern determines the evolution of passenger cars, hybrid electric vehicles (HEV) represent a hub in the automotive sector to reach net-zero CO2 emissions.
Vincenzo De Bellis +2 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A High Efficient Fluid-Structure Interaction Method for Flutter Analysis of Mistuned [PDF]
Xibei Gongye Daxue Xuebao, 2018 The time cost is very high by direct fluid-structure interaction method for mistuned bladed disk structures, so aerodynamic loads generally are ignored or treated as small perturbations in traditional flutter analysis.
doaj +1 more source
A Novel Updated Full-Discretization Method for Prediction of Milling Stability
Micromachines, 2022 This paper presents an updated full-discretization method for milling stability prediction based on cubic spline interpolation. First, the mathematical model of the time-delay milling system considering regenerative chatter is represented by a dynamic ...
Junjin Ma +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2021 With scientific and technological advances, growing research has focused on engineering enzymes that acquire enhanced efficiency and activity. Thereinto, computer-based enzyme modification makes up for the time-consuming and labor-intensive experimental ...
Kun Song +3 more
core +1 more source
A Novel Simplified FE Rail Vehicle Model in Longitudinal and Lateral Collisions
Machines, 2022 It is a challenge to efficiently and accurately predict train dynamic responses during complex collisions. In this paper, a novel numerical simplification method for high-speed rail vehicles during complex impact configurations is proposed.
Gongxun Deng +6 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source