Results 61 to 70 of about 410,375 (269)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

A path to computational efficiency through membrane computing [PDF]

Theoretical Computer Science, 2019
The search for new mechanisms and tools allowing us to tackle the famousPversusNPproblem from new perspectives is an important task, due to the relevance of that problem.The concept of efficiency of computing models is associated with the ability to solveintractable (in a classical sense) problems in polynomial time.
David Orellana-Martín, Luis Valencia-Cabrera, Agustín Riscos-Núñez, Mario J. Pérez-Jiménez   +3 more
openaire   +4 more sources

Tiny-MobileNet-SE: A Hybrid Lightweight CNN Architecture for Resource-Constrained IoT Devices

IEEE Access
Traditional Convolutional Neural Network (CNN) architectures face challenges in deployment on resource-constrained devices such as Internet of Things (IoT) platforms, mobile applications, and drones due to their computational intensity and memory ...
Jean Pierre Nyakuri, Celestin Nkundineza, Omar Gatera, Kizito Nkurikiyeyezu   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Efficient representation of computational meshes [PDF]

International Journal of Computational Science and Engineering, 2009
We present a simple yet general and efficient approach to representation of computational meshes. Meshes are represented as sets of mesh entities of different topological dimensions and their incidence relations. We discuss a straightforward and efficient storage scheme for such mesh representations and efficient algorithms for computation of arbitrary
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Discrete Prompt Compression With Reinforcement Learning

IEEE Access
Compressed prompts aid instruction-tuned language models (LMs) in overcoming context window limitations and reducing computational costs. Existing methods, which are primarily based on training embeddings, face various challenges associated with ...
Hoyoun Jung, Kyung-Joong Kim
doaj   +1 more source

Multi-Cleaning Robots Using Cleaning Distribution Method Based on Map Decomposition in Large Environments

IEEE Access, 2020
Most cleaning robots have a good cleaning performance for small environments such as houses but require a longer cleaning time due to problems such as slow cleaning progress and low battery capacity, making the robots unsuitable for large environments ...
Xu Miao, Hyun-Soon Lee, Bo-Yeong Kang
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effective Efficiency Advantage Assessment of Information Filter for Conventional Kalman Filter in GNSS Scenarios

Sensors, 2019
The Global Navigation Satellite System (GNSS) is a widely used positioning technique. Computational efficiency is crucial to applications such as real-time GNSS positioning and GNSS network data processing.
Yanning Zheng, Siyou Wang, Shengli Wang
doaj   +1 more source