Results 31 to 40 of about 5,454,633 (299)

Engineering Stability, Viscosity, and Immunogenicity of Antibodies by Computational Design.

Journal of Pharmacy and Science, 2020
In recent years, computational methods have garnered much attention in protein engineering. A large number of computational methods have been developed to analyze the sequences and structures of proteins and have been used to predict the various ...
Daisuke Kuroda, K. Tsumoto
semanticscholar   +1 more source

Mitigating Information Overload in Aviation Safety: AI-Driven Hierarchical Tagging and Summarization of NOTAM for Pre-flight Information Bulletin

International Journal of Aviation, Aeronautics, and Aerospace
To address the challenges of aviation safety information overload in Pre-flight Information Bulletin (PIB) systems, this study proposes an intelligent classification framework (ERNIE-DPCNN) that integrates knowledge-enhanced semantic representation with ...
Rutong Gu, Yefeng Qu, Dongling Chen, Yu Tang, Ailin Zhou   +4 more
doaj   +1 more source

Protein engineering in the computational age: An open source framework for exploring mutational landscapes in silico

Engineering Biology, 2023
The field of protein engineering has seen tremendous expansion in the last decade, with researchers developing novel proteins with specialised functionalities for a range of uses, from drug discovery to industrial biotechnology.
Shirin Bamezai, Giovanni Maresca di Serracapriola, Freya Morris, Rasmus Hildebrandt, Marc Augustine Sojerido Amil, Sporadicate iGEM Team, Rodrigo Ledesma‐Amaro   +6 more
doaj   +1 more source

An Integrated Computational Materials Engineering Framework to Analyze the Failure Behaviors of Carbon Fiber Reinforced Polymer Composites for Lightweight Vehicle Applications

Composites Science And Technology, 2020
A bottom-up multi-scale modeling approach is used to develop an Integrated Computational Materials Engineering (ICME) framework for carbon fiber reinforced polymer (CFRP) composites, which has the potential to reduce development to deployment lead time ...
Qingping Sun, Guowei Zhou, Zhaoxu Meng, M. Jain, X. Su   +4 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Computational protein design promises to revolutionize protein engineering

BioTechniques, 2007
Natural evolution has produced an astounding array of proteins that perform the physical and chemical functions required for life on Earth. Although proteins can be reengineered to provide altered or novel functions, the utility of this approach is ...
Oscar Alvizo, Benjamin D. Allen, Stephen L. Mayo   +2 more
doaj   +1 more source

An integrated computational materials engineering-anchored closed-loop method for design of aluminum alloys for additive manufacturing

Materialia, 2020
A closed-loop approach based on integrated computational material engineering was used to design, fabricate and characterize an Al–1.5Cu–0.8Sc–0.4Zr (wt%) alloy for laser powder bed fusion additive manufacturing (AM).
Saket Thapliyal, M. Komarasamy, S. Shukla, Le Zhou, Holden C. Hyer, Sharon Park, Y. Sohn, R. Mishra   +7 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An Energy Approach to the Solution of Partial Differential Equations in Computational Mechanics via Machine Learning: Concepts, Implementation and Applications [PDF]

Computer Methods in Applied Mechanics and Engineering, 2019
Partial Differential Equations (PDE) are fundamental to model different phenomena in science and engineering mathematically. Solving them is a crucial step towards a precise knowledge of the behaviour of natural and engineered systems.
Esteban Samaniego, C. Anitescu, S. Goswami, Vien Minh Nguyen-Thanh, Hongwei Guo, Khader M. Hamdia, T. Rabczuk, X. Zhuang   +7 more
semanticscholar   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source