Results 31 to 40 of about 1,711,553 (293)
Improving Enzyme Fitness with Machine Learning
CHIMIA, 2023 The combinatorial composition of proteins has triggered the application of machine learning in enzyme engineering. By predicting how protein sequence encodes function, researchers aim to leverage machine learning models to select a reduced number of ...
David Patsch, Rebecca Buller
doaj +1 more source
A Framework for Globally Optimizing Mixed-Integer Signomial Programs [PDF]
, 2013 Mixed-integer signomial optimization problems have broad applicability in engineering. Extending the Global Mixed-Integer Quadratic Optimizer, GloMIQO (Misener, Floudas in J. Glob. Optim., 2012. doi:10.1007/s10898-012-9874-7), this manuscript documents a
Floudas, CA, Misener, R
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Applied Sciences, 2023 Artificial intelligence is the branch of computer science that attempts to model cognitive processes such as learning, adaptability and perception to generate intelligent behavior capable of solving complex problems with environmental adaptation and ...
Konstantinos Demertzis +2 more
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Quantum Mechanics with Trajectories: Quantum Trajectories and Adaptive Grids [PDF]
, 2003 Although the foundations of the hydrodynamical formulation of quantum mechanics were laid over 50 years ago, it has only been within the past few years that viable computational implementations have been developed.
Bittner, Eric R., Wyatt, Robert E.
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Advanced Mathematics and Computational Applications in Control Systems Engineering
Mathematical and Computational Applications, 2021 Control-systems engineering is a multidisciplinary subject that applies automatic-control theory to design systems with desired behaviors in control environments [...]
Francisco-Ronay López-Estrada +1 more
doaj +1 more source
Computer program for the design of toroidal transformers [PDF]
, 1973 Program relieves designer of most of the computational details, while he maintains control over most engineering decisions. Number of specifications that must be supplied by user allows for considerable flexibility and for exercise of engineering ...
Dayton, J. A., Jr.
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, 2018 A quantum computer (QC) can solve many computational problems more efficiently than a classic one. The field of QCs is growing: companies (such as DWave, IBM, Google, and Microsoft) are building QC offerings.
Miranskyy, Andriy, Zhang, Lei
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source