Results 61 to 70 of about 1,304,365 (227)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Influence of Agents Heterogeneity in Cellular Model of Evacuation

, 2016
The influence of agents heterogeneity on the microscopic characteristics of pedestrian flow is studied via an evacuation simulation tool based on the Floor-Field model.
Bukáček, Marek, Hrabák, Pavel
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

When Computer Simulation Excels Experiment [PDF]

Biophysical Journal, 2016
For many biophysical problems we have, in general, two approaches. A problem can be studied experimentally, or the corresponding system can be simulated. So far, for the great majority of problems, simulation cannot compete with experiment. Still, simulation seems very attractive because if we solve a problem this way, we can obtain much more ...
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Report on the final panel discussion on computational aeroacoustics [PDF]

Some important conclusions about future prospects for aeroacoustics in general, and for computational aeroacoustics in particular, that were reached in the course of the Final Panel Discussion of the Workshop on Computational Aeroacoustics held from 6 to
Lighthill, James
core   +1 more source

X-ray Astronomy in the Laboratory with a Miniature Compact Object Produced by Laser-Driven Implosion

, 2009
Laboratory spectroscopy of non-thermal equilibrium plasmas photoionized by intense radiation is a key to understanding compact objects, such as black holes, based on astronomical observations.
A Bar-Shalom, A Ng, A H Gabriel, B A Remington, B A Remington, C Rousseaux, C Yamanaka, C B Tarter, David Salzmann, D A Liedahl, D A Liedahl, D E Osterbrock, D R Ballantyne, F Paerels, F Wang, Feilu Wang, G Goldstein, Gang Zhao, G J Ferland, Hideaki Takabe, Hiroaki Nishimura, H K Chung, J Nuckolls, Jae-Min Han, Jie Zhang, Kunioki Mima, M Allen, Minoru Tanabe, M E Foord, Norimasa Yamamoto, N I Shakura, N S Schulz, Quanli Dong, R Giacconi, S Fujioka, S Watanabe, Shinsuke Fujioka, Shoujun Wang, S J Rose, S J Rose, Takashi Fujiwara, T R Kallman, Yi Zhang, Yong-Joo Rhee, Yong-Woo Lee, Yuto Nakabayashi, Yutong Li   +46 more
core   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

Reproducible Econometric Simulations [PDF]

Reproducibility of economic research has attracted considerable attention in recent years. So far, the discussion has focused on reproducibility of empirical analyses.
Achim Zeileis, Christian Kleiber
core  

Hopfield Neural Networks for Online Constrained Parameter Estimation With Time‐Varying Dynamics and Disturbances

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley   +1 more source