Results 281 to 290 of about 757,721 (338)

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

A Perspective on Interactive Theorem Provers in Physics

Advanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Fourier Ambiguity Validation for Carrier-Phase GNSS. [PDF]

Sensors (Basel)
Teunissen PJG.
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Search for thermodynamically stable ambient-pressure superconducting hydrides in the GNoME database. [PDF]

Commun Phys
Sanna A, Cerqueira TFT, Cubuk ED, Errea I, Fang YW.   +4 more
europepmc   +1 more source

First-Principles Thermodynamics of Hydrogen Absorption in Binary C15 Laves Phases. [PDF]

Chem Mater
Paetsch CA, Natarajan AR.
europepmc   +1 more source

ForMileS: A Python Open-Source Program to Generate Molecular Structures for Tandem Mass Spectrometry Fragment Ions. [PDF]

ACS Omega
Kuchenbecker V, Morgon NH.
europepmc   +1 more source

G-D's Physics New "UNCIARE-JRH's AMI Universal Computational Formula" Defies the "Laws of Conservation" & the "Big-Bang Model"!

Jehonathan Bentovish
openalex   +1 more source

DFA-YOLO: Deformable Spatial Attention and Hierarchical Fusion for Robust Object Detection in Adverse Weather. [PDF]

Sensors (Basel)
Xie L, Cheng L.
europepmc   +1 more source

Collaborative optimization of computational offloading and resource allocation based on Stackelberg game. [PDF]

PLoS One
Li L, Yu Q, Wang C, Zhao J, Lv J, Wang S, Hu C.   +6 more
europepmc   +1 more source