Results 31 to 40 of about 155,395 (263)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Price of Upwardness [PDF]

Discrete Mathematics & Theoretical Computer Science
Not every directed acyclic graph (DAG) whose underlying undirected graph is planar admits an upward planar drawing. We are interested in pushing the notion of upward drawings beyond planarity by considering upward $k$-planar drawings of DAGs in which the
Patrizio Angelini, Therese Biedl, Markus Chimani, Sabine Cornelsen, Giordano Da Lozzo, Seok-Hee Hong, Giuseppe Liotta, Maurizio Patrignani, Sergey Pupyrev, Ignaz Rutter, Alexander Wolff   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Optimal Algorithm for the Planar Two-Center Problem [PDF]

TheoretiCS
We study a fundamental problem in Computational Geometry, the planar two-center problem. In this problem, the input is a set $S$ of $n$ points in the plane and the goal is to find two smallest congruent disks whose union contains all points of $S$.
Kyungjin Cho, Eunjin Oh, Haitao Wang, Jie Xue   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Implicit coupled Hilfer–Hadamard fractional differential systems under weak topologies

Advances in Difference Equations, 2018
In this article, we present some existence of weak solutions for a coupled system of implicit fractional differential equations of Hilfer–Hadamard type. Our approach is based on Mönch’s fixed point theorem associated with the technique of measure of weak
Saïd Abbas, Mouffak Benchohra, Naima Hamidi, Yong Zhou   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Computational geometry for sculpture [PDF]

Proceedings of the seventeenth annual symposium on Computational geometry, 2001
This presentation illustrates examples of my geometric sculpture and o utlines certain design techniques. I apply methods from the field of computational geometry to the creation of forms which are aesthetic objects.I am a full- time sculptor creating works that manifest what I call the geometric aesthetic.
openaire   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Coverage improvement using Voronoi diagrams in directional sensor networks

IET Wireless Sensor Systems, 2021
Recently, the area coverage problem has emerged in the directional sensor network (DSN), where the sensor's sensed area depends on its working direction and viewing angle.
Zahra Zarei, Mozafar Bag‐Mohammadi
doaj   +1 more source