Results 41 to 50 of about 814,982 (250)

Optimal Algorithm for the Planar Two-Center Problem [PDF]

TheoretiCS
We study a fundamental problem in Computational Geometry, the planar two-center problem. In this problem, the input is a set $S$ of $n$ points in the plane and the goal is to find two smallest congruent disks whose union contains all points of $S$.
Kyungjin Cho, Eunjin Oh, Haitao Wang, Jie Xue   +3 more
doaj   +1 more source

GRworkbench: A Computational System Based on Differential Geometry [PDF]

, 2001
We have developed a new tool for numerical work in General Relativity: GRworkbench. While past tools have been ad hoc, GRworkbench closely follows the framework of Differential Geometry to provide a robust and general way of computing on analytically ...
Antony, Benjamin J. K. Evans, C. Searle, Susan M. Scott   +3 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Implicit coupled Hilfer–Hadamard fractional differential systems under weak topologies

Advances in Difference Equations, 2018
In this article, we present some existence of weak solutions for a coupled system of implicit fractional differential equations of Hilfer–Hadamard type. Our approach is based on Mönch’s fixed point theorem associated with the technique of measure of weak
Saïd Abbas, Mouffak Benchohra, Naima Hamidi, Yong Zhou   +3 more
doaj   +1 more source

Perception of Motion and Architectural Form: Computational Relationships between Optical Flow and Perspective [PDF]

, 2011
Perceptual geometry refers to the interdisciplinary research whose objectives focuses on study of geometry from the perspective of visual perception, and in turn, applies such geometric findings to the ecological study of vision.
Assadi, Amir H., Mirkia, Hasti, Sangari, Arash   +2 more
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Local and Global Approaches to Fracture Mechanics Using Isogeometric Analysis Method

Journal of Applied and Computational Mechanics, 2015
In the present research, implementations of different computational geometry technologies in isogeometric analysis framework for computational fracture mechanics are investigated.
Abdolghafoor Khademalrasoul, Reza Naderi
doaj   +1 more source