Results 31 to 40 of about 270,552 (263)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

CT radiomic signature predicts survival and chemotherapy benefit in stage I and II HPV-associated oropharyngeal carcinoma

npj Precision Oncology, 2023
Chemoradiation is a common therapeutic regimen for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). However, not all patients benefit from chemotherapy, especially patients with low-risk characteristics.
Bolin Song, Kailin Yang, Vidya Sankar Viswanathan, Xiangxue Wang, Jonathan Lee, Sarah Stock, Pingfu Fu, Cheng Lu, Shlomo Koyfman, James S. Lewis, Anant Madabhushi   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Hyperspectral Image Superresolution via Structure-Tensor-Based Image Matting

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2021
Hyperspectral (HS) imaging has achieved breakthroughs in many applications, such as remote sensing and object recognition. However, the spatial resolution of HS images is still insufficient due to the limitations of sensor technology and cost.
Han Gao, Guifeng Zhang, Min Huang
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Digital-twin-driven unambiguous structured light 3D imaging with physics-aware learning

npj Nanophotonics
Temporal phase unwrapping (TPU) plays a pivotal role in resolving phase ambiguities in fringe projection profilometry (FPP) caused by surface discontinuities or spatially isolated features.
Yiheng Liu, Wenwu Chen, Jinyang Jiang, Shengqi Yu, Ziheng Jin, Xinsheng Li, Shijie Feng, Qian Chen, Chao Zuo   +8 more
doaj   +1 more source

Evolution of cortical geometry and its link to function, behaviour and ecology

Nature Communications, 2023
Studies in comparative neuroanatomy and of the fossil record demonstrate the influence of socio-ecological niches on the morphology of the cerebral cortex, but have led to oftentimes conflicting theories about its evolution.
Ernst Schwartz, Karl-Heinz Nenning, Katja Heuer, Nathan Jeffery, Ornella C. Bertrand, Roberto Toro, Gregor Kasprian, Daniela Prayer, Georg Langs   +8 more
doaj   +1 more source

Compact Shortwave Infrared Imaging Spectrometer Based on a Catadioptric Prism

Sensors, 2022
This article demonstrates a compact prism imaging spectrometer method. A catadioptric curved prism is located at the secondary mirror position of the spectrometer and used to balance the aberrations, enlarge the dispersion width, and decrease the volume.
Lei Feng, Xiaoying He, Yacan Li, Lidong Wei, Yunfeng Nie, Juanjuan Jing, Jinsong Zhou   +6 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source