Results 31 to 40 of about 12,936,285 (295)

Learning Computational Grammars [PDF]

open access: yes, 2001
This paper reports on the LEARNING COMPUTATIONAL GRAMMARS (LCG) project, a postdoc network devoted to studying the application of machine learning techniques to grammars suitable for computational use. We were interested in a more systematic survey
Nerbonne, John   +40 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integrating the Constructionist Learning Theory with Computational Thinking Classroom Activities

open access: yesInformatics in Education, 2019
In computer science education at school, computational thinking has been an emerging topic over the last decade. Even though, computational thinking is interpreted and integrated in classrooms in different ways, an identification process about what ...
Andrew CSIZMADIA   +2 more
doaj   +1 more source

A computational theory of child overextension

open access: yes, 2020
Overextension—the phenomenon that children extend known words to describe referents outside their vocabulary—is a hallmark of lexical innovation in early childhood.
Yang Xu   +2 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

ISAC Integration With Emerging Wireless Network Technologies: A Comprehensive Survey

open access: yesIEEE Open Journal of the Communications Society
Integrated Sensing and Communication (ISAC) has emerged as a fundamental paradigm for Sixth-Generation (6G) wireless networks, enabling the unified use of spectral and hardware resources for simultaneous data transmission and environmental sensing.
Mohamed S. Elbakry   +4 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Next-Gen UAV-Satellite Communications: AI Innovations and Future Prospects

open access: yesIEEE Open Journal of Vehicular Technology
The convergence of sixth-generation (6G) networks with unmanned aerial vehicles (UAVs) and satellites is poised to introduce substantial improvements to the landscape of wireless communication, paving the way for a unified and uninterrupted space-air ...
Sherief Hashima   +5 more
doaj   +1 more source

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