Results 101 to 110 of about 1,176,061 (314)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

A Verification Suite of Test Cases for the Barotropic Solver of Ocean Models

Journal of Advances in Modeling Earth Systems
The development of any atmosphere or ocean model warrants a suite of test cases (TCs) to verify its spatial and temporal discretizations, order of accuracy, stability, reproducibility, portability, scalability, etc.
Siddhartha Bishnu, Mark R. Petersen, Bryan Quaife, Joseph Schoonover   +3 more
doaj   +1 more source

TimeGPT’s Potential in Cryptocurrency Forecasting: Efficiency, Accuracy, and Economic Value

Forecasting
Accurate and efficient cryptocurrency price prediction is vital for investors in the volatile crypto market. This study comprehensively evaluates nine models—including baseline, zero-shot, and deep learning architectures—on 21 major cryptocurrencies ...
Minxing Wang, Pavel Braslavski, Dmitry I. Ignatov   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Force Transition between Atoms and Finite Elements in Quasicontinuum Method and Its Computational Implications

, 2015
Third Asian-Pacific Congress on Computational Mechanics and the Eleventh International Conference on the Enhancement and Promotion of Computational Methods in Engineering and Science國際20071203~20071206紙本YKyoto ...
Chen, C.-S.;Chang, S.-W.;Wang, C.-K.;Liao, Y.-P.;Huang, C.-W., Chen, C.-S.   +1 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Evolutionary genomics : statistical and computational methods [PDF]

, 2019
This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital ...
Anisimova, Maria
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

What Drives Multi-Chain Crypto Forecasting: Model Choice, Feature Selection, and Transferability

Mathematics
Increasingly shaped by heterogeneous on-chain activity rather than a single shared market process, this study investigates 7-day-ahead forecasting using 147 market and on-chain indicators across eight major blockchain ecosystems from October 2023 to ...
Mingxing Wang, Yufeng Xiao, Pavel Braslavski, Dmitry I. Ignatov   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source