Results 101 to 110 of about 14,800,833 (304)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Force Transition between Atoms and Finite Elements in Quasicontinuum Method and Its Computational Implications

open access: yes, 2015
Third Asian-Pacific Congress on Computational Mechanics and the Eleventh International Conference on the Enhancement and Promotion of Computational Methods in Engineering and Science國際20071203~20071206紙本YKyoto ...
Chen, C.-S.;Chang, S.-W.;Wang, C.-K.;Liao, Y.-P.;Huang, C.-W.   +1 more
core  

Computational methods for analyzing and modeling gene regulation and 3D genome organization

open access: yes, 2021
Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, February, 2021Cataloged from the official PDF of thesis.Includes bibliographical references (pages 261-281).Biological processes from differentiation to ...
Belyaeva, Anastasiya.
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Structural degradation assessment of a preheater tower in a cement plant in Peru

open access: yesCase Studies in Construction Materials
This article examines the structural behavior of a paradigmatic case in the cement industry: an existing reinforced concrete (RC) Preheater Tower (PT).
Paula Barboza   +2 more
doaj   +1 more source

Computational Methods in Structural Engineering: Current Advances and Future Perspectives

open access: yes
This brief editorial introduces the Special Issue “Computational Methods in Structural Engineering”. This Special Issue brings together recent advances in computational approaches—including finite element modeling, machine learning ...
Vagelis Plevris   +2 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Computational Fluid-Structure Interaction Methods and Applications

open access: yes, 2013
reference for researchers and practicing engineers who would like to advance their existing knowledge on these subjects. It is also an ideal text for graduate and senior-level undergraduate courses in computational fluid mechanics and computational ...
Bazilevs, Yuri   +2 more
core  

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