Results 81 to 90 of about 1,176,061 (314)

Computational Fluid-Structure Interaction Methods and Applications

open access: yes, 2013
reference for researchers and practicing engineers who would like to advance their existing knowledge on these subjects. It is also an ideal text for graduate and senior-level undergraduate courses in computational fluid mechanics and computational ...
Bazilevs, Yuri   +2 more
core  

Characterization and frequency analysis of flooding solid flow in semi-arid zone: case of Mekerra catchment in the north-west of Algeria

open access: yesApplied Water Science, 2020
In this study, we evaluate the soil erosion and solid transport in the oued Mekerra watershed in north-west Algeria. The study area is subject to a semi-arid climate characterized by irregular rainfall and showers, which are often accompanied by ...
M. Diaf   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Superconducting TaH5 at high pressure

open access: yesNew Journal of Physics, 2019
Recently, the significant development, in the field of high-temperature superconductivity among the compressed elements hydrides (such as LaH _10 ), opens up a door in pursuing room-temperature superconductors.
Hefei Li   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

MOLECULAR ORDER AND DYNAMICS OF 5CB LIQUID CRYSTALS IN CONFINED SPACE – COMPUTER SIMULATION

open access: yesTASK Quarterly, 2015
We studied the dynamical and structural properties of an important nematic 4-n-pentyl-4’-cyanobiphenyl (5CB) mesogen placed near carbon allotropes (graphene, nanotube), using modeling and molecular dynamics simulations (MD).
W. GWIZDAŁA, Z. GBURSKI
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

An overview of recent developments in computational methods for periodic systems

open access: yes, 2007
: At the First IFAC Workshop on Periodic Systems (Como, Italy, 2001), a state of the art survey of computational methods for periodic systems has been presented (Varga and Van Dooren, 2001).
Andras Varga, Varga, Andreas
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

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