Results 61 to 70 of about 1,176,061 (314)

The Southern Annular Mode and Southern Ocean Surface Westerly Winds in E3SM

Earth and Space Science, 2019
Climate variability and change in the Southern Hemisphere (SH) are influenced by the Southern Annular Mode (SAM) and are closely related to changes in the kinematic properties of the SH surface zonal winds.
Doo Young Lee, Mark R. Petersen, Wuyin Lin   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

09421 Abstracts Collection – Algebraic Methods in Computational Complexity [PDF]

, 2010
From 11.10. to 16.10.2009, the Dagstuhl Seminar 09421 ``Algebraic Methods in Computational Complexity '' was held in Schloss Dagstuhl~--~Leibniz Center for Informatics.
Agrawal, Manindra, Umans, Christopher, Thierauf, Thomas, Fortnow, Lance   +3 more
core   +1 more source

Pairwise ratio transformation of gene expression data leads to improved checkpoint response prediction in lung cancer patients

BMC Bioinformatics
Background Machine learning algorithms identify patterns that would otherwise be difficult to observe in high-dimensional molecular and clinical data.
Jacob Pfeil, Liqian Ma, Hin Ching Lo, Tolga Turan, R. Tyler McLaughlin, Xu Shi, Severiano Villarruel, Stephen Wilson, Xi Zhao, Josue Samayoa, Kyle Halliwill   +10 more
doaj   +1 more source

Ribosomal computing: implementation of the computational method

BMC Bioinformatics
Several computational and mathematical models of protein synthesis have been explored to accomplish the quantitative analysis of protein synthesis components and polysome structure. The effect of gene sequence (coding and non-coding region) in protein synthesis, mutation in gene sequence, and functional model of ribosome needs to be explored to ...
Pratima Chatterjee, Prasun Ghosal, Sahadeb Shit, Arindam Biswas 0007, Saurav Mallik, Sarah Allabun, Manal Othman, Almubarak Hassan Ali, E. Elshiekh, Ben Othman Soufiene   +9 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Computational Methods in Wind Engineering

In wind engineering, in parallel to all other engineering disciplines, the impact of computational methods is rapidly increasing. As far as computational aspects are concerned, wind engineering embodies a series of specific challenges, including the ...

core   +1 more source

07411 Abstracts Collection – Algebraic Methods in Computational Complexity [PDF]

, 2008
From 07.10. to 12.10., the Dagstuhl Seminar 07411 ``Algebraic Methods in Computational Complexity'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current
Agrawal, Manindra, Buhrman, Harry, Thierauf, Thomas, Fortnow, Lance   +3 more
core   +1 more source

Discretely Distributed Scheduled Jumps and Interest Rate Derivatives: Pricing in the Context of Central Bank Actions

Economies
Interest rate dynamics are influenced by various economic factors, and central bank meetings play a crucial role concerning this subject matter. This study introduces a novel approach to modeling interest rates, focusing on the impact of central banks ...
Allan Jonathan da Silva, Jack Baczynski
doaj   +1 more source

Brain Perfusion Analysis Method using Computed Tomography Images [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
In this paper, a multi-stage perfusion calculation pipeline is suggested. It contains preprocessing algorithms for brain tissue segmentation, input artery and output vein detection, a self-supervised neural network for CT image denoising, and ...
E. Khudiakova, A. Gavrilov, A. Krylov
doaj   +1 more source