Results 61 to 70 of about 3,015,044 (288)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Brain Perfusion Analysis Method using Computed Tomography Images [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
In this paper, a multi-stage perfusion calculation pipeline is suggested. It contains preprocessing algorithms for brain tissue segmentation, input artery and output vein detection, a self-supervised neural network for CT image denoising, and ...
E. Khudiakova, A. Gavrilov, A. Krylov
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Discretely Distributed Scheduled Jumps and Interest Rate Derivatives: Pricing in the Context of Central Bank Actions

Economies
Interest rate dynamics are influenced by various economic factors, and central bank meetings play a crucial role concerning this subject matter. This study introduces a novel approach to modeling interest rates, focusing on the impact of central banks ...
Allan Jonathan da Silva, Jack Baczynski
doaj   +1 more source

Persistent meanders and eddies lead to quasi-steady Lagrangian transport patterns in a weak western boundary current

Scientific Reports, 2021
The Brazil Current (BC) is a weak western boundary current flowing along the Southwestern Atlantic Ocean. It is frequently described as a flow with intense mesoscale activity and relatively low volume transport between 5.0 and 10.0 Sv.
M. B. Gouveia, R. Duran, J. A. Lorenzzetti, A. T. Assireu, R. Toste, L. P. de F. Assad, D. F. M. Gherardi   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Publisher Correction: Persistent meanders and eddies lead to quasi‑steady Lagrangian transport patterns in a weak western boundary current

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
M. B. Gouveia, R. Duran, J. A. Lorenzzetti, A. T. Assireu, R. Toste, L. P. de F. Assad, D. F. M. Gherardi   +6 more
doaj   +1 more source

Advanced architectural descriptors in foams: novel 3D computational methods [PDF]

, 2013
This work presents 3D computational strategies aimed at providing foam de-structuration of the basic components of a cellular material (struts and cell walls) offering the possibility of analysing separately the structural elements that play an important
Brabant, Loes, Pado-Alonso, Samuel, Rodríguez-Pérez, MA, Solórzano, Eusebio, Van Hoorebeke, Luc, Vicente, J   +5 more
core  

SMaSH: A Benchmarking Toolkit for Human Genome Variant Calling

, 2014
Motivation: Computational methods are essential to extract actionable information from raw sequencing data, and to thus fulfill the promise of next-generation sequencing technology. Unfortunately, computational tools developed to call variants from human
Bresler, Ma'ayan, Curtis, Kristal, Hartl, Christopher, Jordan, Michael I., Liptrap, Jesse, Newcomb, Julie, Patterson, David, Song, Yun S., Talwalkar, Ameet, Terhorst, Jonathan   +9 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source