Results 51 to 60 of about 3,015,044 (288)

Towards efficient modelling of optical micromanipulation of complex structures [PDF]

, 2006
Computational methods for electromagnetic and light scattering can be used for the calculation of optical forces and torques. Since typical particles that are optically trapped or manipulated are on the order of the wavelength in size, approximate ...
Branczyk, A. M., Heckenberg, N. R., Loke, V. L. Y., Nieminen, T. A., Rubinsztein-Dunlop, H.   +4 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Segmentation of Foreground Row Trees in Apple Orchard Images Collected by Ground Vehicles [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
This paper proposes a fully automatic method for the segmentation of foreground row trees in industrial apple orchard images. The segmentation is based on analyzing a combination of a depth map constructed by the Marigold diffusion model and a model ...
M. A. Merzliakova, B. M. Shurygin, A. E. Solovchenko, A. S. Krylov, D. V. Sorokin   +4 more
doaj   +1 more source

Solving systems of phaseless equations via Kaczmarz methods: A proof of concept study [PDF]

, 2015
We study the Kaczmarz methods for solving systems of quadratic equations, i.e., the generalized phase retrieval problem. The methods extend the Kaczmarz methods for solving systems of linear equations by integrating a phase selection heuristic in each ...
Wei, Ke
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A posteriori error estimation for model order reduction of parametric systems

Advanced Modeling and Simulation in Engineering Sciences
This survey discusses a posteriori error estimation for model order reduction of parametric systems, including linear and nonlinear, time-dependent and steady systems.
Lihong Feng, Sridhar Chellappa, Peter Benner   +2 more
doaj   +1 more source

The Southern Annular Mode and Southern Ocean Surface Westerly Winds in E3SM

Earth and Space Science, 2019
Climate variability and change in the Southern Hemisphere (SH) are influenced by the Southern Annular Mode (SAM) and are closely related to changes in the kinematic properties of the SH surface zonal winds.
Doo Young Lee, Mark R. Petersen, Wuyin Lin   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pairwise ratio transformation of gene expression data leads to improved checkpoint response prediction in lung cancer patients

BMC Bioinformatics
Background Machine learning algorithms identify patterns that would otherwise be difficult to observe in high-dimensional molecular and clinical data.
Jacob Pfeil, Liqian Ma, Hin Ching Lo, Tolga Turan, R. Tyler McLaughlin, Xu Shi, Severiano Villarruel, Stephen Wilson, Xi Zhao, Josue Samayoa, Kyle Halliwill   +10 more
doaj   +1 more source

Discontinuities without discontinuity: The Weakly-enforced Slip Method [PDF]

, 2013
Tectonic faults are commonly modelled as Volterra or Somigliana dislocations in an elastic medium. Various solution methods exist for this problem. However, the methods used in practice are often limiting, motivated by reasons of computational efficiency
Gutiérrez, M. A., Hanssen, R. F., van Brummelen, E. H., van der Zee, K. G., van Zwieten, G. J.   +4 more
core   +2 more sources