Results 51 to 60 of about 14,800,833 (304)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding [PDF]

, 2021
Computational approaches in drug discovery and development hold great promise, with artificial intelligence methods undergoing widespread contemporary use, but the experimental validation of these new approaches is frequently inadequate.
Uta, Lessel, Kristina, Edfeldt, Matthew H., Todd, John J., Irwin, Benjamin G. , Perry, Cora, Scholten, Ingo, Muegge, Ulrich A.K., Betz, Michael K., Gilson, Andrea, Volkamer, Johanna M. , Jansen, Rommie E., Amaro, Ian, Dunham, Kumar Singh, Saikatendu, Matthieu, Schapira, Cheryl H., Arrowsmith, John, Moult, Aled M., Edwards, John D., Chodera, Wendy D., Cornell, Timothy M. , Willson, Gerhard, Hessler, Cristian G., Bologa, Claudia R., Gordijo, Andrew R., Leach, Daniel, Kuhn, Anders, Hogner, Gerhard F., Ecker, Rima, Al-awar, Yoshua, Bengio, Tudor I., Oprea, Patrick, Riley, Suzanne, Ackloo, Hatylas, Azevedo, Alexander, Hillisch, Alpha A., Lee, Vijayaratnam, Santhakumar, Robert A., Batey, Masoud, Vedadi   +38 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Reusability-targeted enrichment of sea ice core data

Scientific Data
The Reusability-targeted Enriched Sea Ice Core Database (RESICE) combines data and metadata from 287 sea ice cores. The database enables reuse scenarios such as the validation of physics-based models and the training of data-driven algorithms.
Anna Simson, Anil Yildiz, Julia Kowalski
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Computational Methods in Wind Engineering

In wind engineering, in parallel to all other engineering disciplines, the impact of computational methods is rapidly increasing. As far as computational aspects are concerned, wind engineering embodies a series of specific challenges, including the ...

core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

EVALUATION OF ACQUISITION STRATEGIES FOR IMAGE-BASED CONSTRUCTION SITE MONITORING [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
Construction site monitoring is an essential task for keeping track of the ongoing construction work and providing up-to-date information for a Building Information Model (BIM).
S. Tuttas, S. Tuttas, A. Braun, A. Braun, A. Borrmann, A. Borrmann, U. Stilla, U. Stilla   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source