Results 51 to 60 of about 1,176,061 (314)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of Ligand Binding to GPCRs Through Computational Methods

, 2017
The recent increase in available G protein-coupled receptor structures now contributes decisively to the structure-based ligand design. In this context, computational approaches in combination with medicinal chemistry and pharmacology are extremely ...
Silvana Vasile, Vasile, Silvana,, Jespers, Willem,, Hugo Gutiérrez-de-Terán, Mauricio Esguerra, Sallander, Jessica,, Oliveira, Ana,, Åqvist, Johan,, Ana Oliveira, Willem Jespers, Jessica Sallander, Johan Åqvist, Gutiérrez-de-Terán, Hugo,, Esguerra, Mauricio,   +13 more
core   +1 more source

Extrapolation methods for PageRank computations

Comptes Rendus. Mathématique, 2005
The mathematical problem behind Web search is the computation of the nonnegative left eigenvector of a stochastic matrix P corresponding to the dominant eigenvalue 1. This vector is called the PageRank vector. Since the matrix P
Brezinski, Claude, Redivo-Zaglia, Michela, Serra-Capizzano, Stefano   +2 more
openaire   +4 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Segmentation of Foreground Row Trees in Apple Orchard Images Collected by Ground Vehicles [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
This paper proposes a fully automatic method for the segmentation of foreground row trees in industrial apple orchard images. The segmentation is based on analyzing a combination of a depth map constructed by the Marigold diffusion model and a model ...
M. A. Merzliakova, B. M. Shurygin, A. E. Solovchenko, A. S. Krylov, D. V. Sorokin   +4 more
doaj   +1 more source

A manifesto for the computational method

Theoretical Computer Science, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

04421 Abstracts Collection – Algebraic Methods in Computational Complexity [PDF]

, 2005
From 10.10.04 to 15.10.04, the Dagstuhl Seminar 04421 ``Algebraic Methods in Computational Complexity'' was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Buhrman, Harry, Thierauf, Thomas, Fortnow, Lance   +2 more
core   +1 more source

A posteriori error estimation for model order reduction of parametric systems

Advanced Modeling and Simulation in Engineering Sciences
This survey discusses a posteriori error estimation for model order reduction of parametric systems, including linear and nonlinear, time-dependent and steady systems.
Lihong Feng, Sridhar Chellappa, Peter Benner   +2 more
doaj   +1 more source