Results 41 to 50 of about 14,800,833 (304)
A computational and theoretical investigation of the accuracy of quasicontinuum methods [PDF]
, 2011 We give computational results to study the accuracy of several quasicontinuum methods for two benchmark problems – the stability of a Lomer dislocation pair under shear and the stability of a lattice to plastic slip under tensile loading.
Luskin, Mitchell Barry +7 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2018 The optimal control of moving boundary problems receives growing attention in science and technology. We consider the so called two-phase Stefan problem that models a solid and a liquid phase separated by a moving interface. The Stefan problem is coupled
Baran Bjőrn +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Evolutionary genomics : statistical and computational methods [PDF]
, 2019 This open access book addresses the challenge of analyzing and understanding the evolutionary dynamics of complex biological systems at the genomic level, and elaborates on some promising strategies that would bring us closer to uncovering of the vital ...
Anisimova, Maria
core +2 more sources
Bayesian Computational Methods [PDF]
, 2011 In this chapter, we will first present the most standard computational challenges met in Bayesian Statistics, focussing primarily on mixture estimation and on model choice issues, and then relate these problems with computational solutions. Of course, this chapter is only a terse introduction to the problems and solutions related to Bayesian ...
openaire +6 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
GeFaST: An improved method for OTU assignment by generalising Swarm’s fastidious clustering approach
BMC Bioinformatics, 2018 Background Massive genomic data sets from high-throughput sequencing allow for new insights into complex biological systems such as microbial communities. Analyses of their diversity and structure are typically preceded by clustering millions of 16S rRNA
Robert Müller, Markus E. Nebel
doaj +1 more source
Not All Computational Methods Are Effective Methods [PDF]
Philosophies, 2022 An effective method is a computational method that might, in principle, be executed by a human. In this paper, I argue that there are methods for computing that are not effective methods. The examples I consider are taken primarily from quantum computing, but these are only meant to be illustrative of a much wider class.
openaire +2 more sources