Results 91 to 100 of about 3,015,044 (288)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Structural degradation assessment of a preheater tower in a cement plant in Peru

Case Studies in Construction Materials
This article examines the structural behavior of a paradigmatic case in the cement industry: an existing reinforced concrete (RC) Preheater Tower (PT).
Paula Barboza, Enzo Martinelli, Guillermo Etse   +2 more
doaj   +1 more source

Female vs. Male Ampelmännchen-Gender-Specific Reaction Times to Male and Female Traffic Light Figures

Frontiers in Psychology, 2017
Traffic signs are important visual guiding signals for the safe navigation through complex road traffic. Interestingly, there is little variation in the traffic signs for cars around the world.
Farid I. Kandil, Farid I. Kandil, Bettina Olk, Bettina Olk, Claus C. Hilgetag, Claus C. Hilgetag   +5 more
doaj   +1 more source

Computational methods for ideal compressible flow [PDF]

Conservative dissipative difference schemes, the recognition and representation of discontinuities, and multidimensional methods are ...
Vanleer, B.
core   +1 more source

Imprecise continuous-time Markov chains : efficient computational methods with guaranteed error bounds [PDF]

, 2017
Imprecise continuous-time Markov chains are a robust type of continuous-time Markov chains that allow for partially specified time-dependent parameters. Computing inferences for them requires the solution of a non-linear differential equation.
De Bock, Jasper, Erreygers, Alexander
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Particle approximations of the score and observed information matrix for parameter estimation in state space models with linear computational cost

, 2015
Poyiadjis et al. (2011) show how particle methods can be used to estimate both the score and the observed information matrix for state space models. These methods either suffer from a computational cost that is quadratic in the number of particles, or ...
Fearnhead, Paul, Mihaylova, Lyudmila, Nemeth, Christopher   +2 more
core   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A Verification Suite of Test Cases for the Barotropic Solver of Ocean Models

Journal of Advances in Modeling Earth Systems
The development of any atmosphere or ocean model warrants a suite of test cases (TCs) to verify its spatial and temporal discretizations, order of accuracy, stability, reproducibility, portability, scalability, etc.
Siddhartha Bishnu, Mark R. Petersen, Bryan Quaife, Joseph Schoonover   +3 more
doaj   +1 more source

TimeGPT’s Potential in Cryptocurrency Forecasting: Efficiency, Accuracy, and Economic Value

Forecasting
Accurate and efficient cryptocurrency price prediction is vital for investors in the volatile crypto market. This study comprehensively evaluates nine models—including baseline, zero-shot, and deep learning architectures—on 21 major cryptocurrencies ...
Minxing Wang, Pavel Braslavski, Dmitry I. Ignatov   +2 more
doaj   +1 more source