Results 81 to 90 of about 15,734,175 (308)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Modeling and Validation of High-Pressure Hydrogen Joule-Thomson Effect for Enhanced Hydrogen Energy System Safety

Energies
With the rapid development of hydrogen fuel cell vehicles, the research on the throttling effect of high-pressure hydrogen is crucial to the safety of hydrogen circulation systems for fuel cells. This paper studies the Joule-Thomson coefficients (μJT) of
Mu-Yao Zhou, Yi Fang, Qian-Hua Wang, Yi-Ming Dai, Zhan-Hao Liu, Ji-Qiang Li, Jeong-Tae Kwon   +6 more
doaj   +1 more source

Cholinergic modulation of cognitive processing: insights drawn from computational models

Frontiers in Behavioral Neuroscience, 2012
Acetylcholine plays an important role in cognitive function, as shown by pharmacological manipulations that impact working memory, attention, episodic memory and spatial memory function.
Ehren L Newman, Kishan eGupta, Jason R Climer, Caitlin K Monaghan, Michael E Hasselmo   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Reputation Without Practice? A Dynamic Computational Model of the Unintended Consequences of Open Scientist Reputations

Journal of Trial and Error
Practicing open science can have benefits for the career prospects of individual researchers or labs through higher quality work and increased chances of publication.
Maximilian~Linde, Merle-Marie~Pittelkow, Nina~R.~Schwarzbach, Don~van~Ravenzwaaij   +3 more
doaj   +1 more source

A model of electrophysiological heterogeneity in periglomerular cells

Frontiers in Computational Neuroscience, 2013
Olfactory bulb periglomerular (PG) cells are heterogeneous with respect to several features, including morphology, connectivity, patterns of protein expression, and electrophysiological properties.
Praveen eSethupathy, Praveen eSethupathy, Daniel B. Rubin, Daniel B. Rubin, Guoshi eLi, Thomas A. Cleland   +5 more
doaj   +1 more source

Sub-series 2: Publications

, 1989
Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Advances in Astrocyte Computational Models: From Metabolic Reconstructions to Multi-omic Approaches

Frontiers in Neuroinformatics, 2020
The growing importance of astrocytes in the field of neuroscience has led to a greater number of computational models devoted to the study of astrocytic functions and their metabolic interactions with neurons. The modeling of these interactions demands a
Janneth González, Andrés Pinzón, Andrea Angarita-Rodríguez, Andrea Angarita-Rodríguez, Andrés Felipe Aristizabal, George E. Barreto, George E. Barreto, Cynthia Martín-Jiménez   +7 more
doaj   +1 more source

Pergamon Acropolis Model

, 1950
Detail, Temple of Dionysus at lowest point, center, Temple of Trajan (2nd century CE) in courtyard, theater, lower right; Pergamon was an ancient Greek city in Asia Minor (now Bergama, Turkey), later part of the Roman Empire.
unknown (German model maker)
core