Results 81 to 90 of about 26,976,188 (312)

Cholinergic modulation of cognitive processing: insights drawn from computational models

Frontiers in Behavioral Neuroscience, 2012
Acetylcholine plays an important role in cognitive function, as shown by pharmacological manipulations that impact working memory, attention, episodic memory and spatial memory function.
Ehren L Newman, Kishan eGupta, Jason R Climer, Caitlin K Monaghan, Michael E Hasselmo   +4 more
doaj   +1 more source

Dramatis: A Computational Model of Suspense

AAAI Conference on Artificial Intelligence, 2014
We introduce Dramatis, a computational model of suspense based on a reformulation of a psychological definition of the suspense phenomenon. In this reformulation, suspense is correlated with the audience’s ability to generate a plan for the ...
Brian O'Neill, Mark O. Riedl
semanticscholar   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Reputation Without Practice? A Dynamic Computational Model of the Unintended Consequences of Open Scientist Reputations

Journal of Trial and Error
Practicing open science can have benefits for the career prospects of individual researchers or labs through higher quality work and increased chances of publication.
Maximilian~Linde, Merle-Marie~Pittelkow, Nina~R.~Schwarzbach, Don~van~Ravenzwaaij   +3 more
doaj   +1 more source

A model of electrophysiological heterogeneity in periglomerular cells

Frontiers in Computational Neuroscience, 2013
Olfactory bulb periglomerular (PG) cells are heterogeneous with respect to several features, including morphology, connectivity, patterns of protein expression, and electrophysiological properties.
Praveen eSethupathy, Praveen eSethupathy, Daniel B. Rubin, Daniel B. Rubin, Guoshi eLi, Thomas A. Cleland   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Advances in Astrocyte Computational Models: From Metabolic Reconstructions to Multi-omic Approaches

Frontiers in Neuroinformatics, 2020
The growing importance of astrocytes in the field of neuroscience has led to a greater number of computational models devoted to the study of astrocytic functions and their metabolic interactions with neurons. The modeling of these interactions demands a
Janneth González, Andrés Pinzón, Andrea Angarita-Rodríguez, Andrea Angarita-Rodríguez, Andrés Felipe Aristizabal, George E. Barreto, George E. Barreto, Cynthia Martín-Jiménez   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Impact of vascular density on pancreatic islet viability: a computational study

Frontiers in Physiology
IntroductionPancreatic islets are densely vascularized clusters of cells that secrete insulin, glucagon, and somatostatin, hormones essential to glucose metabolism.
Gerardo J. Félix-Martínez, Lizbeth de la Cruz, Daniel Whisman, J. Rafael Godínez-Fernández   +3 more
doaj   +1 more source