Results 71 to 80 of about 26,598,097 (313)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
EnergiesWith the rapid development of hydrogen fuel cell vehicles, the research on the throttling effect of high-pressure hydrogen is crucial to the safety of hydrogen circulation systems for fuel cells. This paper studies the Joule-Thomson coefficients (μJT) of
Mu-Yao Zhou +6 more
doaj +1 more source
Models of Models: A Translational Route for Cancer Treatment and Drug Development
Frontiers in Oncology, 2017 Every patient and every disease is different. Each patient therefore requires a personalized treatment approach. For technical reasons, a personalized approach is feasible for treatment strategies such as surgery, but not for drug-based therapy or drug ...
Lesley A. Ogilvie +5 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Journal of Trial and ErrorPracticing open science can have benefits for the career prospects of individual researchers or labs through higher quality work and increased chances of publication.
Maximilian~Linde +3 more
doaj +1 more source
Cholinergic modulation of cognitive processing: insights drawn from computational models
Frontiers in Behavioral Neuroscience, 2012 Acetylcholine plays an important role in cognitive function, as shown by pharmacological manipulations that impact working memory, attention, episodic memory and spatial memory function.
Ehren L Newman +4 more
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A model of electrophysiological heterogeneity in periglomerular cells
Frontiers in Computational Neuroscience, 2013 Olfactory bulb periglomerular (PG) cells are heterogeneous with respect to several features, including morphology, connectivity, patterns of protein expression, and electrophysiological properties.
Praveen eSethupathy +5 more
doaj +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Advances in Astrocyte Computational Models: From Metabolic Reconstructions to Multi-omic Approaches
Frontiers in Neuroinformatics, 2020 The growing importance of astrocytes in the field of neuroscience has led to a greater number of computational models devoted to the study of astrocytic functions and their metabolic interactions with neurons. The modeling of these interactions demands a
Janneth González +7 more
doaj +1 more source