Results 71 to 80 of about 26,976,188 (312)
Computer Methods in Biomechanics and Biomedical Engineering, 2014 A three-dimensional (3D) knee joint computational model was developed and validated to predict knee joint contact forces and pressures for different degrees of malalignment.
R. Mootanah +13 more
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
(Mal)adaptive Mentalizing in the Cognitive Hierarchy, and Its Link to Paranoia
Computational PsychiatryHumans need to be on their toes when interacting with competitive others to avoid being taken advantage of. Too much caution out of context can, however, be detrimental and produce false beliefs of intended harm.
Nitay Alon +5 more
doaj +1 more source
Modelling Alzheimer’s disease: from past to future
Frontiers in Pharmacology, 2013 Alzheimer’s disease (AD) is emerging as the most prevalent and socially disruptive illness of aging populations, as more people live long enough to become affected. Although AD is placing a considerable and increasing burden on society, it represents the
Claudia eSaraceno +4 more
doaj +1 more source
When, why and how tumour clonal diversity predicts survival
Evolutionary Applications, 2020 The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood.
Robert Noble +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Fractal and FractionalThis work develops a Boundary Element Method (BEM) formulation for simulating bioheat transfer in perfused biological tissues using the Atangana–Baleanu fractional derivative in the Caputo sense (ABC).
Mohamed Abdelsabour Fahmy, Ahmad Almutlg
doaj +1 more source
Models of Models: A Translational Route for Cancer Treatment and Drug Development
Frontiers in Oncology, 2017 Every patient and every disease is different. Each patient therefore requires a personalized treatment approach. For technical reasons, a personalized approach is feasible for treatment strategies such as surgery, but not for drug-based therapy or drug ...
Lesley A. Ogilvie +5 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
EnergiesWith the rapid development of hydrogen fuel cell vehicles, the research on the throttling effect of high-pressure hydrogen is crucial to the safety of hydrogen circulation systems for fuel cells. This paper studies the Joule-Thomson coefficients (μJT) of
Mu-Yao Zhou +6 more
doaj +1 more source