Results 51 to 60 of about 15,734,175 (308)
Cell Reports, 2016 Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery.
George Kastellakis +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Postsynaptic signal transduction models for long-term potentiation and depression
Frontiers in Computational Neuroscience, 2010 More than a hundred biochemical species, activated by neurotransmitters binding to transmembrane receptors, are important in long-term potentiation and depression.
Tiina Manninen +5 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Journal of Rock Mechanics and Geotechnical EngineeringIn this paper, we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils. Our approach combines a Gaussian process regression (GPR)-based surrogate model with random cell-based smoothed finite ...
H.C. Nguyen +6 more
doaj +1 more source
Frontiers in Neural Circuits, 2016 The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing.
Scott Rich +2 more
doaj +1 more source
Frontiers in Physiology, 2023 Acute myocardial ischemia induces hyperkalemia (accumulation of extracellular potassium), a major perpetrator of lethal reentrant ventricular arrhythmias.
Jose M. Ferrero +3 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A Computational Model of Working Memory Based on Spike-Timing-Dependent Plasticity
Frontiers in Computational Neuroscience, 2021 Working memory is closely involved in various cognitive activities, but its neural mechanism is still under exploration. The mainstream view has long been that persistent activity is the neural basis of working memory, but recent experiments have ...
Qiu-Sheng Huang, Hui Wei
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source