Results 31 to 40 of about 26,976,188 (312)

Advancing the Network Theory of Mental Disorders: A Computational Model of Panic Disorder

, 2019
The network theory of psychopathology posits that mental disorders are complex systems of mutually reinforcing symptoms. This overarching framework has proven highly generative but does not specify precisely how any specific mental disorder operates as ...
Donald Robinaugh, Jonas M. B. Haslbeck, L. Waldorp, J. Kossakowski, Eiko I. Fried, A. Millner, R. McNally, E. V. van Nes, M. Scheffer, K. Kendler, D. Borsboom   +10 more
semanticscholar   +1 more source

Typologies of Computation and Computational Models

CoRR, 2013
We need much better understanding of information processing and computation as its primary form. Future progress of new computational devices capable of dealing with problems of big data, internet of things, semantic web, cognitive robotics and neuroinformatics depends on the adequate models of computation.
Mark Burgin, Gordana Dodig-Crnkovic
openaire   +2 more sources

The Nature of Computational Models

Computing in Science & Engineering, 2023
Computational models lie at the heart of computational science. And yet, few scientists have a clear idea of what a computational model actually is. Is it software? Or an algorithm? How does it relate to mathematical models? What are suitable languages or notations for expressing a computational model in the literature?
openaire   +2 more sources

Computer modelling of monoamine oxidases [PDF]

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2015
The article summarized results of studies on active site structures of monoamine oxidases (MAO) performed in the Institute of Biomedical Chemistry (Russia) by computer modelling approaches. MAO, catalyzing the reaction of oxidative deamination of major neurotransmitter monoamines, exists in two highly homologous forms, MAO A and MAO B, distinguished by
A V, Veselovsky, A S, Ivanov, A E, Medvedev   +2 more
openaire   +2 more sources

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Cell, 2012
SUMMARY Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle.
Jonathan R. Karr, Jayodita C. Sanghvi, Derek N. Macklin, Miriam V. Gutschow, J. M. Jacobs, Benjamin Bolival, N. Assad-Garcia, J. Glass, M. Covert   +8 more
semanticscholar   +1 more source

Neuronal and Astrocytic Regulations in Schizophrenia: A Computational Modelling Study

Frontiers in Cellular Neuroscience, 2021
According to the tripartite synapse model, astrocytes have a modulatory effect on neuronal signal transmission. More recently, astrocyte malfunction has been associated with psychiatric diseases such as schizophrenia.
Lea Fritschi, Johanna Hedlund Lindmar, Florian Scheidl, Kerstin Lenk, Kerstin Lenk   +4 more
doaj   +1 more source

Towards a General-Purpose Foundation Model for Computational Pathology

Nature Medicine
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks, requiring the objective characterization of histopathological entities from whole-slide images (WSIs).
Richard J. Chen, Tong Ding, Ming Y. Lu, Drew F. K. Williamson, Guillaume Jaume, Andrew H. Song, Bowen Chen, Andrew Zhang, Daniel Shao, M. Shaban, Mane Williams, Lukas Oldenburg, Luca L. Weishaupt, Judy J. Wang, Anurag Vaidya, L. Le, Georg K. Gerber, S. Sahai, Walt Williams, Faisal Mahmood   +19 more
semanticscholar   +1 more source

A visual-language foundation model for computational pathology

Nature Medicine
The accelerated adoption of digital pathology and advances in deep learning have enabled the development of robust models for various pathology tasks across a diverse array of diseases and patient cohorts.
Ming Y. Lu, Bowen Chen, Drew F. K. Williamson, Richard J. Chen, Ivy Liang, Tong Ding, Guillaume Jaume, Igor Odintsov, L. Le, Georg K. Gerber, Anil V Parwani, Andrew Zhang, Faisal Mahmood   +12 more
semanticscholar   +1 more source

Development and Validation of a Computational Model for Androgen Receptor Activity

Chemical Research in Toxicology, 2016
Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods.
N. Kleinstreuer, P. Ceger, Eric D Watt, Matt T. Martin, K. Houck, P. Browne, Russell S. Thomas, W. Casey, D. Dix, D. Allen, S. Sakamuru, M. Xia, Ruili Huang, R. Judson   +13 more
semanticscholar   +1 more source

TMS-evoked responses are driven by recurrent large-scale network dynamics

eLife, 2023
A compelling way to disentangle the complexity of the brain is to measure the effects of spatially and temporally synchronized systematic perturbations.
Davide Momi, Zheng Wang, John D Griffiths   +2 more
doaj   +1 more source