Results 41 to 50 of about 15,734,175 (308)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Grothendieck computability model
Theoretical Computer ScienceTranslating notions and results from category theory to the theory of computability models of Longley and Normann, we introduce the Grothendieck computability model and the first-projection-simulation. We prove some basic properties of the Grothendieck computability model, and we show that the category of computability models is a type-category, in the
Gambarte, Luis, Petrakis, Iosif
openaire +4 more sources
A DNA computing inspired computational model
Theoretical Computer Science, 2008 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
FRANCO, Giuditta, M. Margenstern
openaire +2 more sources
, 2021 Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum, Daniels, Timothy J.
core +1 more source
A Smart Data Hub to integrate subsurface properties into model-based decision-support tools
Scientific DataThe selection of suitable nuclear waste disposal sites is a long and challenging process, involving multiple technical and environmental assessments. For data-integrated simulation models to function as credible decision-support tools in this sensitive ...
Qian Chen +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The ADaptation and Anticipation Model (ADAM) of sensorimotor synchronization
Frontiers in Human Neuroscience, 2013 A constantly changing environment requires precise yet flexible timing of movements. Sensorimotor synchronization (SMS) —the temporal coordination of an action with events in a predictable external rhythm— is a fundamental human skill that contributes to
Maria Christine Van Der Steen +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Cooperation among Virtual Anthropoids in a Complex Environment [PDF]
Interdisciplinary Description of Complex Systems, 2011 This paper presents an agent based model of the evolution of cooperation in a complex environment. Anthropoid agents reproduce sexually, and live in a world where food is irregularly distributed in space and seasonally produced. They can share food, form
Jakson Alves de Aquino
doaj