Results 41 to 50 of about 26,598,097 (313)

Cooperation among Virtual Anthropoids in a Complex Environment [PDF]

Interdisciplinary Description of Complex Systems, 2011
This paper presents an agent based model of the evolution of cooperation in a complex environment. Anthropoid agents reproduce sexually, and live in a world where food is irregularly distributed in space and seasonally produced. They can share food, form
Jakson Alves de Aquino
doaj  

The ADaptation and Anticipation Model (ADAM) of sensorimotor synchronization

Frontiers in Human Neuroscience, 2013
A constantly changing environment requires precise yet flexible timing of movements. Sensorimotor synchronization (SMS) —the temporal coordination of an action with events in a predictable external rhythm— is a fundamental human skill that contributes to
Maria Christine Van Der Steen, Peter E. Keller, Peter E. Keller   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

A DNA computing inspired computational model

Theoretical Computer Science, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
FRANCO, Giuditta, M. Margenstern
openaire   +2 more sources

Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites

Cell Reports, 2016
Memories are believed to be stored in distributed neuronal assemblies through activity-induced changes in synaptic and intrinsic properties. However, the specific mechanisms by which different memories become associated or linked remain a mystery.
George Kastellakis, Alcino J. Silva, Panayiota Poirazi   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Postsynaptic signal transduction models for long-term potentiation and depression

Frontiers in Computational Neuroscience, 2010
More than a hundred biochemical species, activated by neurotransmitters binding to transmembrane receptors, are important in long-term potentiation and depression.
Tiina Manninen, Katri Hituri, Jeanette eHellgren Kotaleski, Jeanette eHellgren Kotaleski, Kim T. Blackwell, Marja-Leena Linne   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A COMPUTATIONAL MODEL OF MOTOR NEURON DEGENERATION

Neuron, 2014
SUMMARY To explore the link between bioenergetics and motor neuron degeneration, we used a computational model in which detailed morphology and ion conductance are paired with intracellular ATP production and consumption.
G. Le Masson, S. Przedborski, L. Abbott
semanticscholar   +1 more source

Intrinsic Cellular Properties and Connectivity Density Determine Variable Clustering Patterns in Randomly Connected Inhibitory Neural Networks

Frontiers in Neural Circuits, 2016
The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing.
Scott Rich, Victoria Booth, Michal Zochowski   +2 more
doaj   +1 more source