Results 61 to 70 of about 26,976,188 (312)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Integrating Immunotherapy With Targeted Therapy: Evaluating Efficacy in NSCLC Treatment Through Computational Analysis of Gene Regulatory Networks

IEEE Access
Non-Small Cell Lung Cancer (NSCLC) remains a leading cause of cancer-related deaths, often characterized by complex mutational landscapes and resistance to monotherapies.
Pranabesh Bhattacharjee, Aditya Lahiri, Tanmay Sindhwani, Norman Peter Reeves, Aniruddha Datta   +4 more
doaj   +1 more source

Towards an integrative computational model of the guinea pig cardiac myocyte

Frontiers in Physiology, 2012
The local control theory of excitation-contraction (EC) coupling asserts that regulation of calcium (Ca2+) release occurs at the nanodomain level, where openings of single L-type Ca2+ channels (LCCs) trigger openings of small clusters of ryanodine ...
Laura Doyle Gauthier, Joseph L Greenstein, Raimond L Winslow   +2 more
doaj   +1 more source

A Closed-Loop Modeling Framework for Cardiac-to-Coronary Coupling

Frontiers in Physiology, 2022
The mechanisms by which cardiac mechanics effect coronary perfusion (cardiac-to-coronary coupling) remain incompletely understood. Several coronary models have been proposed to deepen our understanding of coronary hemodynamics, but possibilities for in ...
Anneloes G. Munneke, Joost Lumens, Theo Arts, Tammo Delhaas   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Computational models of neurophysiological correlates of tinnitus

Frontiers in Systems Neuroscience, 2012
The understanding of tinnitus has progressed considerably in the past decade, but the details of the mechanisms that give rise to this phantom perception of sound without a corresponding acoustic stimulus have not been pinpointed yet.
Roland eSchaette, Richard eKempter
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Computational Models of Attention

, 2014
This chapter reviews recent computational models of visual attention. We begin with models for the bottom-up or stimulus-driven guidance of attention to salient visual items, which we examine in seven different broad categories. We then examine more complex models which address the top-down or goal-oriented guidance of attention towards items that are ...
Laurent Itti, Ali Borji
openaire   +2 more sources

Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection

eLife
Locomotion is controlled by spinal circuits that interact with supraspinal drives and sensory feedback from the limbs. These sensorimotor interactions are disrupted following spinal cord injury. The thoracic lateral hemisection represents an experimental
Ilya A Rybak, Natalia A Shevtsova, Johannie Audet, Sirine Yassine, Sergey N Markin, Boris I Prilutsky, Alain Frigon   +6 more
doaj   +1 more source

Detecting Global form: separate processes required for Glass and Radial Frequency patterns.

Frontiers in Computational Neuroscience, 2013
Global processing of form information has been studied extensively using both Glass and radial frequency patterns. Models, with common early stages, have been proposed for the detection of properties of both pattern types but human performance has not ...
David Russel Badcock, Renita A Almeida, J Edwin Dickinson   +2 more
doaj   +1 more source