Results 61 to 70 of about 26,598,097 (313)
Computational models of neurophysiological correlates of tinnitus
Frontiers in Systems Neuroscience, 2012 The understanding of tinnitus has progressed considerably in the past decade, but the details of the mechanisms that give rise to this phantom perception of sound without a corresponding acoustic stimulus have not been pinpointed yet.
Roland eSchaette, Richard eKempter
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Computational Models of Attention
, 2014 This chapter reviews recent computational models of visual attention. We begin with models for the bottom-up or stimulus-driven guidance of attention to salient visual items, which we examine in seven different broad categories. We then examine more complex models which address the top-down or goal-oriented guidance of attention towards items that are ...
Laurent Itti, Ali Borji
openaire +2 more sources
Computer Methods in Biomechanics and Biomedical Engineering, 2014 A three-dimensional (3D) knee joint computational model was developed and validated to predict knee joint contact forces and pressures for different degrees of malalignment.
R. Mootanah +13 more
semanticscholar +1 more source
(Mal)adaptive Mentalizing in the Cognitive Hierarchy, and Its Link to Paranoia
Computational PsychiatryHumans need to be on their toes when interacting with competitive others to avoid being taken advantage of. Too much caution out of context can, however, be detrimental and produce false beliefs of intended harm.
Nitay Alon +5 more
doaj +1 more source
Detecting Global form: separate processes required for Glass and Radial Frequency patterns.
Frontiers in Computational Neuroscience, 2013 Global processing of form information has been studied extensively using both Glass and radial frequency patterns. Models, with common early stages, have been proposed for the detection of properties of both pattern types but human performance has not ...
David Russel Badcock +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Fractal and FractionalThis work develops a Boundary Element Method (BEM) formulation for simulating bioheat transfer in perfused biological tissues using the Atangana–Baleanu fractional derivative in the Caputo sense (ABC).
Mohamed Abdelsabour Fahmy, Ahmad Almutlg
doaj +1 more source
Modelling Alzheimer’s disease: from past to future
Frontiers in Pharmacology, 2013 Alzheimer’s disease (AD) is emerging as the most prevalent and socially disruptive illness of aging populations, as more people live long enough to become affected. Although AD is placing a considerable and increasing burden on society, it represents the
Claudia eSaraceno +4 more
doaj +1 more source
When, why and how tumour clonal diversity predicts survival
Evolutionary Applications, 2020 The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an evolutionary process that is not well understood.
Robert Noble +3 more
doaj +1 more source