Results 21 to 30 of about 364,009 (218)

A qualitatively validated mathematical-computational model of the immune response to the yellow fever vaccine

BMC Immunology, 2018
Background Although a safe and effective yellow fever vaccine was developed more than 80 years ago, several issues regarding its use remain unclear. For example, what is the minimum dose that can provide immunity against the disease?
Carla R. B. Bonin, Guilherme C. Fernandes, Rodrigo W. dos Santos, Marcelo Lobosco   +3 more
doaj   +1 more source

Enhancing Railway Detection by Priming Neural Networks with Project Exaptations

Remote Sensing, 2022
When integrating railway constructions and refurbishments into an existing infrastructure, it is beneficial to have knowledge of the exact state, geometry, and placement of the connected assets.
Felix Eickeler, André Borrmann
doaj   +1 more source

Particulate Matter Forecasting Using Different Deep Neural Network Topologies and Wavelets for Feature Augmentation

Atmosphere, 2022
The concern about air pollution in urban areas has substantially increased worldwide. One of its main components, particulate matter (PM) with aerodynamic diameter of ≤2.5 µm (PM2.5), can be inhaled and deposited in deeper regions of the respiratory ...
Stephanie Lima Jorge Galvão, Júnia Cristina Ortiz Matos, Yasmin Kaore Lago Kitagawa, Flávio Santos Conterato, Davidson Martins Moreira, Prashant Kumar, Erick Giovani Sperandio Nascimento   +6 more
doaj   +1 more source

Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks

Scientific Reports, 2023
Cardiac Purkinje networks are a fundamental part of the conduction system and are known to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje networks remains a challenge due to their high morphological complexity ...
Lucas Arantes Berg, Bernardo Martins Rocha, Rafael Sachetto Oliveira, Rafael Sebastian, Blanca Rodriguez, Rafael Alves Bonfim de Queiroz, Elizabeth M. Cherry, Rodrigo Weber dos Santos   +7 more
doaj   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology

Human Vaccines & Immunotherapeutics, 2017
New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology.
Carla Rezende Barbosa Bonin, Guilherme Cortes Fernandes, Rodrigo Weber dos Santos, Marcelo Lobosco   +3 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

PET-MAD as a lightweight universal interatomic potential for advanced materials modeling

Nature Communications
Machine-learning interatomic potentials have greatly extended the reach of atomic-scale simulations, offering the accuracy of first-principles calculations at a fraction of the cost.
Arslan Mazitov, Filippo Bigi, Matthias Kellner, Paolo Pegolo, Davide Tisi, Guillaume Fraux, Sergey Pozdnyakov, Philip Loche, Michele Ceriotti   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source