Results 41 to 50 of about 364,009 (218)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On the Identifiability of Relative Permeability and Foam Displacement Parameters in Porous Media Flow

Water Resources Research
This study focuses on analyzing parameter identifiability in foam displacement models during two‐phase flow in porous media, with a particular emphasis on calibrating relative permeability and foam parameters.
L. S. Ribeiro, G. B. Miranda, B. M. Rocha, G. Chapiro, R. Weber dos Santos   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modelling post-chemotherapy stem cell dynamics in the bone marrow niche of AML patients

Scientific Reports
Acute myeloid leukemia (AML) is a stem cell-driven malignancy of the blood forming (hematopoietic) system. Despite of high dose chemotherapy with toxic side effects, many patients eventually relapse.
Chenxu Zhu, Thomas Stiehl
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

YOLOv11-HBDY: A Unified Hybrid Model Integrating NAM-R, CBH-R, and Ghost Convolutions for Multi-task Mpox Lesion Analysis

Human-Centric Intelligent Systems
Recent mpox (monkeypox) outbreaks have intensified global public health concerns and underscored the urgent demand for accurate, scalable, and accessible diagnostic systems.
Fernando Rodrigues Trindade Ferreira, Loena Marins do Couto   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Comparing the Latent Features of Universal Machine‐Learning Interatomic Potentials

Advanced Intelligent Systems
The past few years have seen the development of “universal” machine‐learning interatomic potentials (uMLIPs) capable of approximating the ground‐state potential energy surface across a wide range of chemical structures and compositions with reasonable ...
Sofiia Chorna, Davide Tisi, Cesare Malosso, Wei Bin How, Michele Ceriotti, Sanggyu Chong   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enhancing context awareness in augmented reality environments: a review of opportunities and challenges in object and action recognition through machine learning

Discover Applied Sciences
Augmented reality environments face significant challenges in achieving context and semantic awareness, which are relevant for enhancing user experiences.
Iolanda L. Chamusca, Tiago P. Pagano, Rafael B. Loureiro, Erick G. S. Nascimento, Alex Á. B. Santos, Yiyu Cai, Thiago B. Murari, Ingrid Winkler   +7 more
doaj   +1 more source