Results 51 to 60 of about 4,253,827 (311)
Computational modeling in developmental psychology
, 2007 This manuscript surveys computational modeling efforts by researchers in developmental psychology. Developmental psychology is ready to blossom into a modern science that focuses on causal mechanistic explanations of development rather than just ...
Thomas, Michael S.C. +2 more
core +1 more source
PET-MAD as a lightweight universal interatomic potential for advanced materials modeling
Nature CommunicationsMachine-learning interatomic potentials have greatly extended the reach of atomic-scale simulations, offering the accuracy of first-principles calculations at a fraction of the cost.
Arslan Mazitov +8 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2020 The first-principle modeling of heterogeneous catalysts is a revolutionarily approach, as the electronic structure of a catalyst is closely related to its reactivity on the surface with reactant molecules.
Jongmin Park +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Energies, 2021 This article presents studies related to the driving and control of the switched reluctance generator in order to enhance its efficiency. This type of electrical machine is an option for wind energy conversion systems, favoring the generation of ...
Wanderson R. H. Araujo +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Dealing with diversity in computational cancer modeling [PDF]
, 2013 25.02.15 KB. Ok to add published version to spiral, OA paperThis paper discusses the need for interconnecting computational cancer models from different sources and scales within clinically relevant scenarios to increase the accuracy of the models and ...
Wang, Zhihui +26 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Interharmonics: Theory and Modeling
, 2007 Some of the most remarkable issues related to interharmonic theory and modeling are presented. Starting from the basic definitions and concepts, attention is first devoted to interharmonic sources.
IEEE TASK FORCE ON HARMONICS MODELING a. S. +2 more
core +1 more source