Results 61 to 70 of about 2,017,547 (269)

Representations of Sensory Signals and Abstract Categories in Brain Networks

, 2021
Many recent advances in artificial intelligence (AI) are rooted in visual neuroscience. However, ideas from more complicated paradigms like decision-making are less used.
Pinotsis, Dimitris, Miller, Earl K, Siegel, Markus, Pinotsis, Dimitrios, Miller, Earl   +4 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Computational and Mathematical Methods for Neuroscience

Applied Sciences
As our understanding of the brain continues to advance, so too does the demand for sophisticated tools that can model, simulate, and interpret the intricate data generated by contemporary neuroimaging and electrophysiological techniques [...]
Alexander N. Pisarchik
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Looking for effects of qualia on event-related brain potentials of close others in search for a cause of the similarity of qualia assumed across individuals [version 3; referees: 2 approved]

F1000Research, 2018
Qualia, the individual instances of subjective conscious experience, are private events. However, in everyday life, we assume qualia of others and their perceptual worlds, to be similar to ours.
Sheila Bouten, Hugo Pantecouteau, J. Bruno Debruille   +2 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Computational Cognitive Neuroscience [PDF]

, 2018
This chapter provides an overview of the basic research strategies and analytic techniques deployed in computational cognitive neuroscience. On the one hand, “top-down” (or reverse-engineering) strategies are used to infer, from formal characterizations ...
Carlos Zednik, Zednik, Carlos
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Toward Reference-Grade neuron models

Communications Biology
Computational neuroscience increasingly produces detailed, data-driven neuron models, yet compressing biological variability and measurement uncertainty into single-parameter sets can blur the line between data-supported claims and modeling choices. Here,
Alon Korngreen
doaj   +1 more source

The computational neuroscience of head direction cells [PDF]

, 2011
Head direction cells signal the orientation of the head in the horizontal plane. This thesis shows how some of the known head direction cell response properties might develop through learning.
Walters, Daniel Matthew
core   +1 more source