Results 71 to 80 of about 8,550,305 (373)

Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology

Human Vaccines & Immunotherapeutics, 2017
New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology.
Carla Rezende Barbosa Bonin, Guilherme Cortes Fernandes, Rodrigo Weber dos Santos, Marcelo Lobosco   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Looking for Design in Materials Design

, 2004
Despite great advances in computation, materials design is still science fiction. The construction of structure-property relations on the quantum scale will turn computational empiricism into true design.Comment: 3 pages, 1 ...
CS Smith, D. P. Clougherty, L Chang, LEK Achenie, M. E. Eberhart, RB Woodward   +5 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Computational Archival Science [PDF]

Moderna arhivistika, 2018
The digitisation of archival materials and ingest of digitally born materials in digital archives has led to the possibilities of application of the big data analytical principles in the digital archives. The author explains the 5V characteristics of big data. He proceeds to define the concept of Computational Archival Science (CAS).
openaire   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

For a heterodox computational social science

Big Data & Society, 2021
The proliferation of digital data has been the impetus for the emergence of a new discipline for the study of social life: ‘computational social science’.
Petter Törnberg, Justus Uitermark
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Towards a computational transportation science

Journal of Spatial Information Science, 2011
This report of a community activity, a Dagstuhl Seminar earlier in 2010, postulates the need for a computational transportation science, as the science behind intelligent transportation systems.
Stephan Winter, Monika Sester, Ouri Wolfson, Glenn Geers   +3 more
doaj   +3 more sources

Credimus

, 2019
We believe that economic design and computational complexity---while already important to each other---should become even more important to each other with each passing year. But for that to happen, experts in on the one hand such areas as social choice,
A Appel, A Shamir, C Lund, D Barrington, J Hartmanis, J Hartmanis, J Hartmanis, J Lutz, J Storer, J-Y Cai, L Fortnow, L Hemaspaandra, L Hemaspaandra, Michael Sipser, Moshe Y. Vardi, N Immerman, N Nisan, R Szelepcsényi, S Arora, S Kurtz, S Toda, W Gasarch   +21 more
core   +1 more source