Results 61 to 70 of about 2,446,572 (290)

A Meta-Theory of Boundary Detection Benchmarks [PDF]

open access: yes, 2012
Human labeled datasets, along with their corresponding evaluation algorithms, play an important role in boundary detection. We here present a psychophysical experiment that addresses the reliability of such benchmarks. To find better remedies to evaluate
Hou, Xiaodi   +2 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Computational Communication Science| Computational Communication Science: A Methodological Catalyzer for a Maturing Discipline

open access: yesInternational Journal of Communication, 2019
This article reviews the opportunities and challenges for computational research methods in the field of communication. Among the social sciences, communication stands out as a discipline with a relatively low-profile institutionalized focus on the in ...
Martin Hilbert   +15 more
doaj  

Model Creation and Equivalence Proofs of Cellular Automata and Artificial Neural Networks

open access: yes, 2020
Computational methods and mathematical models have invaded arguably every scientific discipline forming its own field of research called computational science. Mathematical models are the theoretical foundation of computational science.
Christen, Patrik
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

MANIFESTO OF COMPUTATIONAL SOCIAL SCIENCE

open access: yesMediações: Revista de Ciências Sociais, 2013
The increasing integration of technology into our lives has created unprecedented volumes of data on society’s everyday behaviour. Such data opens up exciting new opportunities to work towards a quantitative understanding of our complex social systems ...
Rosaria Conte   +13 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Motifs in self-organising cells

open access: yesMachine Learning: Science and Technology
In complex systems, groups of interacting objects may form prevalent and persistent spatiotemporal patterns, which we refer to as motifs. These motifs can exhibit features that reveal how individual objects interact with one another.
Ying Chen Lim   +3 more
doaj   +1 more source

CICT: New Eyes on Computational Competence in Computational Science

open access: yesITM Web of Conferences, 2018
Science does not exists to enlighten people's minds only. It mainly exists to show the educated way from quanta to qualia. And that way starts from computational competence. In previous papers published elsewhere, we have already shown that traditional Q
Fiorini Rodolfo A.
doaj   +1 more source

Special Issue “Computational Social Science”

open access: yesInformation, 2019
The last centuries have seen a great surge in our understanding and control of “simple” physical, chemical, and biological processes through data analysis and the mathematical modeling of their underlying dynamics [...]
Gerardo Iñiguez   +2 more
doaj   +1 more source

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